When rotenone is added to actively respiring bovine mitochondria, the ratio of NADH to NAD+ increases but the FADH2 to FAD ratio remains unchanged.            a. What step in the system is being inhibited by rotenone?                  b. What would be the effect of rotenone on pyruvate oxidation to CO2?                              ____________________ Why?

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter22: Medications Used For Gastrointestinal System Disorders
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When rotenone is added to actively respiring bovine mitochondria, the ratio of NADH to NAD+ increases but the FADH2 to FAD ratio remains unchanged.

 

         a. What step in the system is being inhibited by rotenone?

 

 

 

 

         b. What would be the effect of rotenone on pyruvate oxidation to CO2?

                             ____________________ Why?

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