affinity of a protein-protein or protein-ligand interaction can be described by theDissociation Constant, Kd (written below). Consider a protein P and its inhibitor,I.I inhibits P's activity when bound to it:koff _ [A][B]Dissociation Constant: Ka=koN[AB]QuestionWhen [I] is 10-7 M, 99% of P's activity is inhibited. What is the Kd of this Protein-Inhibitor interaction?

Protein can function as enzymes, signal molecule, ligand, receptor, etc. Its function can be…

Answered: When [I] is 10-7 M, 99% of P's activity…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

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Problem 1P

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When [I] is 10-7 M, 99% of P's activity is inhibited. What is the Kd of this Protein- Inhibitor interaction?