When a naïve or memory T orB cell is activated by antigen andco-stimulatory signals, how does itdecide whether to become an effectorcell or memory cell? Are there cellsthat are pre-committed to becomingeither effector or memory cells, forexample, or is the decision determinedsolely by extracellular signals?
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When a naïve or memory T or
B cell is activated by antigen and
co-stimulatory signals, how does it
decide whether to become an effector
cell or memory cell? Are there cells
that are pre-committed to becoming
either effector or memory cells, for
example, or is the decision determined
solely by extracellular signals?
Step by step
Solved in 2 steps
- Why is it necessary for immature T lymphocytes toundergo a two-step selection process through whichantigen-reactive cells are first selected followed bythe elimination of cells that react strongly withself-antigens?Some primitive organisms, such as invertebrates, have no lymphocytes and thus lack an adaptive immune system, but they have somecomponents of an innate immune system, including phagocytes andcertain protective proteins. What are some general features of innateimmunity that make it very valuable to organisms lacking more specific antibody- and cell-mediated responses? What are some disadvantages to having only an innate immune system?that causes the rapid reproduction of a specific ( Select] [ Select ] Antigenic cell B cell I cell Macrophage Eosinophil Vaccines work by stimulating a(n) [Select ] that produces an antibody that is specific for the antigen in the vaccine. This creates a pool of memory cells that will be available if the person is ever infect nicrobe.
- What is the associationbetween inflammation andfever?At first glance, it would seem a dangerous strategyfor the thymus to actively promote the survival, matura-tion, and emigration of developing T cells that bind weaklyto self peptides bound to self MHC molecules. Would itnot be safer to get rid of these T cells, along with those thatbind strongly to such self-peptide–MHC complexes, as thiswould seem a more secure way to avoid autoimmune reac-tions?What is the differencebetween humoral specificimmune response and cellularspecific immune response?
- List two different types of phagocytes. How do Tcells and B cells differ in their functions? From where inthe human body do all of these cells originate and whichrequire maturation before they are functional?What is the defensemechanism that begins towork when inflammation failsto stop an infection?Put the following steps in order for cell-mediated immunereactions:(a) Differentiated T cells include T helper, delayed hyper-sensitivity, cytotoxic, and memory T cells that all havedifferent immunological functions depending on the an-tigen presented.(b) Antigen-presenting cells (macrophages and dendriticcells) phagocytize pathogens, ingesting and degradingthem into pieces which are transported to the surface ofthe cell.(c) T cells bearing the corresponding receptor for the pre-sented antigen bind to it and become activated only ifthe appropriate MHC is also present.(d) Some pieces of the pathogen’s antigens are processedby inserting them into the antigen-presenting cell’smembrane and are held in place by class II majorhistocompatibility complex (MHCII) proteins.(e) Activated T cells are stimulated to divide and differen-tiate into different types of T cells, including memorycells
- If you had to choose between losing function of your B or T cells, which would you choose, and why?Compare and contrast the roles and activities of the differentTh cells. What cytokines do they produce, and which effectorcells do these cytokines act upon?What mechanism do Tc cells use to identify anddestroy infected cells in the body? How do Th cells differfrom Tc cells, and how do the different subsets of Thcells differ from each other?