What will be the effect of the following changes to the protein structure of hemoglobin and its function? A. Replacement of the proximal histidine residue at the 8thposition of the F helix by asparagine. B. A phenylalanine to proline mutation resulting in decreased cooperativity of the polypeptide chains. C. Replacement of a nonpolar amino acid in the interior of the protein to a hydrophilic amino acid.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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What will be the effect of the following changes to the protein structure of hemoglobin and its function?

A. Replacement of the proximal histidine residue at the 8thposition of the F helix by asparagine.

B. A phenylalanine to proline mutation resulting in decreased cooperativity of the polypeptide chains.

C. Replacement of a nonpolar amino acid in the interior of the protein to a hydrophilic amino acid.

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