What ore the innate response external and internal defenses? or barriers?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Innate - Immune System - detail if possible thanks trying to better understand it
**Title: Understanding Innate Immunity: External and Internal Defenses**

**Introduction**

The innate immune system serves as the body's first line of defense against pathogens. It is composed of external and internal defenses that work together to protect the body from infection.

**External Defenses (Barriers)**

External defenses, often referred to as barriers, include the physical and chemical structures that prevent pathogens from entering the body. Here are some key components:

1. **Skin:** Acts as a physical barrier with tough, outer layers that are difficult for pathogens to penetrate.
2. **Mucous Membranes:** Line many of the body’s openings and secrete mucus to trap pathogens.
3. **Secretions:** Such as saliva, tears, and stomach acid, that contain enzymes and acids to destroy pathogens.

**Internal Defenses**

Once pathogens bypass external barriers, internal defenses are activated. These include:

1. **Phagocytic Cells:** Such as macrophages and neutrophils, which engulf and digest invaders.
2. **Natural Killer Cells:** Destroy infected or cancerous cells by inducing apoptosis.
3. **Inflammatory Response:** Involves increased blood flow and immune cell activity to the affected area, helping to isolate and attack the pathogen.
4. **Antimicrobial Proteins:** Proteins like interferons that interfere with viral replication.

Understanding these innate immune responses is crucial in appreciating how our body defends itself against daily microbial threats.
Transcribed Image Text:**Title: Understanding Innate Immunity: External and Internal Defenses** **Introduction** The innate immune system serves as the body's first line of defense against pathogens. It is composed of external and internal defenses that work together to protect the body from infection. **External Defenses (Barriers)** External defenses, often referred to as barriers, include the physical and chemical structures that prevent pathogens from entering the body. Here are some key components: 1. **Skin:** Acts as a physical barrier with tough, outer layers that are difficult for pathogens to penetrate. 2. **Mucous Membranes:** Line many of the body’s openings and secrete mucus to trap pathogens. 3. **Secretions:** Such as saliva, tears, and stomach acid, that contain enzymes and acids to destroy pathogens. **Internal Defenses** Once pathogens bypass external barriers, internal defenses are activated. These include: 1. **Phagocytic Cells:** Such as macrophages and neutrophils, which engulf and digest invaders. 2. **Natural Killer Cells:** Destroy infected or cancerous cells by inducing apoptosis. 3. **Inflammatory Response:** Involves increased blood flow and immune cell activity to the affected area, helping to isolate and attack the pathogen. 4. **Antimicrobial Proteins:** Proteins like interferons that interfere with viral replication. Understanding these innate immune responses is crucial in appreciating how our body defends itself against daily microbial threats.
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