what is the sequence of peptide 1?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
use one-letter code for the amino acid if needed
what is the sequence of peptide 1?

Transcribed Image Text:A NONAPEPTIDE that attacks and kills cancer cells has just been recently isolated from a rare fungus. Amino
acid analysis of the peptide reveals the following information below: (NOTE: when the sequence is not known,
a comma separates the amino acids)
Hydrazine
Acid Hydrolysis (6 N HCI) at 110°C
Nonapeptide
(2) Arg, Gln, (2) Tyr, Gly, Ser, Thr, and Met
2,4-dinitrofluorobenzene
DNP-Thr
Gin and
modified free
amino acids
Peptide 1
(Arg, Thr, Ser)
Cleavage with Trypsin, then chromatography
Peptide 2
(Gly, Tyr, Arg)
Met
Tripeptide
Cyanogen bromide
Dipeptide
Peptide 3
(Arg, Ser, Tyr, Thr)
Cleavage with Chymotrypsin, then chromatography
Amino acid
Peptide 4
(Gly, Arg, Tyr)
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