What is the multiple testing problem? Why is the Bonferroni adjustment conservative for GWAS dataanalysis? Suppose you are conducting two parallel and identical GWA studies (using the Affymetrix500k GeneChip platform), one study in a European population and one in an African population. Forwhich study would the Bonferroni adjustment be more conservative - European or African? Why?

Answered: Image /qna-images/answer/1a5b235c-a205-4ac4-baad-61e2d1ba78eb.jpg

Answered: What is the multiple testing problem?…

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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Define the components of a well-designed experimental design (independent vs dependent variable, control vs experimental groups, sampling size, random assignment and blinded studies).
What is the difference between treatment variability and error variability in factorial Designs?
In which of these research designs would you have complete control of the environment? Cohort Cross-sectional Experimental Case-Control
Find the test statistic and conclusion
Acne is a common skin disease that affects most adolescents and can continue into adulthood. A study compared the effectiveness of three acne treatments and a placebo, all in gel form, applied twice daily for 12 weeks. The study's 517 teenage volunteers were randomly assigned to one of the four treatments. Success was assessed as clear or almost clear skin at the end of the 12 week period. The results of the study can be seen in the table below. Using the appropriate statistical test, determine if there is significant evidence that the four treatments perform differently. If so, how do they compare.
The calculations for a factorial experiment involving four levels of factor A, three levels of factor B, and three replications resulted in the following data: SST = 271, SSA = 22, SSB = 24, SSAB = 170. Set up the ANOVA table and test for any significant main effect and may interaction effect. use a= .05.
The National Longitudinal Study of Adolescent Health interviewed several thousand teens (grades 7 to 12). One question asked was “What do you think are the chances you will be married in the next 10 years?” Here is a two-way table of the responses by gender: Opinion Female Male Almost no chance 120 94 Some chance but probably not 156 178 A 50-50 chance 427 498 A good chance 750 700 Almost certain 1176 770 How many individuals are described in this table? How many females were among the respondents? The percent of females among the respondents was about %. Your percent from the previous exercise is part of the marginal distribution of opinion about marriage. the conditional distribution of sex among adolescents with a given opinion. the marginal distribution of sex. What percent of females thought that they were almost certain to be married in the next 10 years?% Your percent from the previous exercise is part of the conditional distribution of sex among…
If no main effects emerge in a two-factor ANOVA, there must also be no significant interaction between the two factors. Group of answer choices True False
for a two way factor anova comparing the possible interaction between religion and anxiety, what is the alternative
For an ANOVA comparing three treatment conditions, what is stated by the null hypothesis (HO)? Question 1 options: There are no differences between any of the population means. At least one of the three population means is different from another mean. All three of the population means are different from each other. None of the other choices is correct.
On a trial basis, State College admitted 300 students from the lowest third of their high school graduation class. They were randomly divided into 3 groups. Group A received extensive training in study habits Group B received motivational lectures; and Group C received no special treatment. At the end of the year, the average grades of the groups were compared. Identify the following: * What is the Independent variable? * What is the Dependent variable? * Who is in the Experimental Group? * Who is in the Control Group? * What are at least 2 potential extraneous variables?
Design a two-factor ANOVA with variables of interest (personal, academic, career). In addition state your 3 hypothesis (2 main effects, 1 interaction). Example: Two-Factor ANOVA to evaluate the effect of Video Game Violence and Grade on Aggression Factors1. Factor A: Video Game Violence level (3 levels: low, moderate, high) 2. Factor B: Grade level (4 levels: 1st grade, 2nd grade, 3rd grade, 4th grade) 3. Dependent Variable: Aggression Hypothesis Tests1. Video Game Violence level affects Aggression2. Grade level affects Aggression 3. Interaction between Video Game Violence level and Grade level: video game violence level will affect aggression but only for 3rd and 4th graders but not for 1st and 2nd graders. INCLUDED ABOVE IS AN EXAMPLE. THIS IS NOT AN ESSAY QUESTION OR INCOMPLETE. THIS HAS BEEN REJECTED TWICE PLEASE DON'T DO THE SAME.

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