What is the mechanism for the esterification of vanillin to vanillyl acetate, under basic conditions, using acetic anhdyride? Include a balanced reaction and all the products

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

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Q: What product is formed by the addition of NaHCO3 to p-toluic acid?

A: p-toluic acid is a substituted benzoic acid. Structure of p-toluic acid :-

Q: Obtain by synthesis the compound 3-phenylpropanoic acid by an acetylacetic or malonic synthesis.

A: The objective of this question is to outline the steps to synthesize 3-phenylpropanoic acid using an…

Q: Through an acetoacetic or malonic synthesis, obtain cyclopentanecarboxylic acid. Put the drawings of…

A: Step 1: Malonic ester (Diethyl malonate) on treatment with base (sodium ethoxide) gives an enolate,…

Q: Give the relative rates of reaction of the four carboxylic acid derivatives below with aqueous…

A: The reactivity of the acyl compound depends on the partial positive charge present on the carbonyl…

Q: Please provide a balanced chemical equation for the following reactions: 2-naphthol + NaOH…

A: 2-Naphthol has the following structure:

Q: Draw a flow-chart for the separation of benzoic acid and ethyl benzoate . Which compound can be…

A: Separation process is used for separating the components present in a mixture. There are various…

Q: Describe six way to prepare to 1-pentanamine and write two ways reaction routrs to obtain 1-pentene…

A: 1-pentanamine can be prepared in prepared by several ways. Following are the 6 ways to prepare…

Q: What is the product when ethylbbenzoate is treated with excess ethanamine?

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Q: can an ester be synthesized by grignard reagent?

A: Grignard reagent: The strong carbon nucleophile that reacts with carbonyl group forming alcohols.

Q: Which of the following would be least water soluble? formaldehyde 2-butanone 3-heptanone propanal…

A: Carbonyl compounds interact with water by dipole-dipole interaction. Water molecules have dipoles…

Q: Show how the malonic ester synthesis makes substituted acetic acids, and how theacetoacetic ester…

A: The mechanism for the malonic ester is shown below.

Q: How would you dispose of diphenylacetic acid?

A: Diphenyl acetic acid may be harmful if inhaled.

Q: What is difference between the acetoacetic and malonic ester syntheses? Provide an example of each,…

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Q: Outline a synthesis of acetylcholine iodide using dimethylamine, oxirane, iodomethane, and acetyl…

A: Oxiranes are potential intermediate for the synthesis of variety of functional groups. Oxiranes /…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.