What is the advantage of using superficially porous particles?
Superficially porous particles are those particles made from non porous core and porous shell material that has properties similar to fully porous particles. The first superficially porous particles were developed by Horvath and Kirkland to enhance the performance of RPLC with large biomolcules.
The main advantage of using superficially porous particles are that it can show properties of both porous and non porous particles. Apart from that it can be used in the analysis of large biomolecules in chromatography as it enhances the column efficiency, provide better kinetic performance, the eddy diffusion term of columns packed with superficially porous particles are significantly smaller, lower sample loading and retention compared to fully porous particles etc...
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