What forms the basis of tetranucleotide hypothesis for DNA structure ?

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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What forms the basis of tetranucleotide hypothesis for DNA structure ?

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American biochemist Phoebus Aaron Theodore Levene investigated the structure and function of nucleic acids. He distinguished between DNA and RNA, the two types of nucleic acid. He also discovered adenine, guanine, thymine, cytosine, deoxyribose, and a phosphate group in DNA. Before Erwin Chargaff's later work, it was commonly assumed that DNA was arranged into repeating tetranucleotides in such a way that genetic information could not be carried. Instead, it was thought that the protein component of chromosomes was the source of heredity; prior to the 1940s, most studies on the physical origin of the gene concentrated on proteins, particularly enzymes and viruses.

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