What charge at pencentage of the Histidane side chain will PH = 7₁4? Cerrry No.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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how did we get the number 1x10^6?and 3.98x10^-8?explain??where these number come from?
midterm
ego sup
Pka-
10.01.2016
What pencentage of the Histidine side chain will
charge at pH = 7.4?
NHIIHI
LNH+]
->
Pka INHI
[4+]
=
1x106
INHI 3.98×108
-
25
1
25
INHI IS 26 = 96%
Ans 96%
Carry No.
Transcribed Image Text:midterm ego sup Pka- 10.01.2016 What pencentage of the Histidine side chain will charge at pH = 7.4? NHIIHI LNH+] -> Pka INHI [4+] = 1x106 INHI 3.98×108 - 25 1 25 INHI IS 26 = 96% Ans 96% Carry No.
©2003 Brooks/Cole, a division of Thomson Learning, Inc.
TABLE 3.2 pk Values of Common Amino Acids
Acid
RH or RH
Gly
Ala
Val
Leu
Ile
Ser
Thr
Met
Phe
Trp
Asn
Gln
Pro
Asp
Glu
His
Cys
Tyr
- Lys
Arg
a-COOH
TAN
2.34
2.34
2.32
2.36
2.36
2.21
2.63
2.28
1.83
2.38
2.02
2.17
1.99
2.09
2.19
1.82
1.71
2.20
2.18
2.17
a-NH
9.60
9.69
9.62
9.68
9.68
9.15
10.43
9.21
9.13
9.39
8.80
9.13
10.6
9.82
9.67
9.17
10.78
9.11
8.95
9.04
3.86*
4.25*
6.0*
8.33*
Table 3.2 PKa values of common amino acids
10.07
10.53
12.48
18
For these amino acids the R group ionization occurs before the a-NH;
ionization.
RH
group
Transcribed Image Text:©2003 Brooks/Cole, a division of Thomson Learning, Inc. TABLE 3.2 pk Values of Common Amino Acids Acid RH or RH Gly Ala Val Leu Ile Ser Thr Met Phe Trp Asn Gln Pro Asp Glu His Cys Tyr - Lys Arg a-COOH TAN 2.34 2.34 2.32 2.36 2.36 2.21 2.63 2.28 1.83 2.38 2.02 2.17 1.99 2.09 2.19 1.82 1.71 2.20 2.18 2.17 a-NH 9.60 9.69 9.62 9.68 9.68 9.15 10.43 9.21 9.13 9.39 8.80 9.13 10.6 9.82 9.67 9.17 10.78 9.11 8.95 9.04 3.86* 4.25* 6.0* 8.33* Table 3.2 PKa values of common amino acids 10.07 10.53 12.48 18 For these amino acids the R group ionization occurs before the a-NH; ionization. RH group
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