what are the clinical implications of measuring alkaline phosphatase isomers and their activity ?
Alkaline phosphatase isomers are a group of isoenzymes with low substrate specificity that catalyzes the hydrolysis of phosphate esters in basic conditions. It is found in several tissues of the body and predominantly present in the liver and bone. The normal level of alkaline phosphatase in serum varies between 20-140 units per liter (U/L). Children and pregnant women were found to have a higher level of alkaline phosphatase in serum. Damage in the tissues containing alkaline phosphatase results in its release into the blood. An abnormal level of alkaline phosphatase in serum indicates the disorders in the liver or bone.
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