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Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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Question
Warfarin (coumadin) binds to human plasma albumin to prevent blood clotting in the reaction
Measured thermodynamic values for this reaction at 25oC are ∆G =-30.8 kJ/mol, ∆H=-13.1 kJ/mol, and ∆Cp~0.
(a) Determine the entropy change for this reaction at 25oC.
(b) Determine the fraction of unbound albumin over a temperature range of 0 to 50oC for a solution initially containing warfarin and albumin at 0.1 mM.
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