Using the principles of soft-drugs, design a short acting version of sildenafil.You must draw your structure in the hand-in sheet.ΗΝN

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Answered: Using the principles of soft-drugs,…

Chemistry In Focus

7th Edition

ISBN:9781337399692

Author:Tro, Nivaldo J.

Publisher:Tro, Nivaldo J.

Chapter17: Drugs And Medicine: Healing, Helping, And Hurting

Section: Chapter Questions

Problem 63E

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4. Below are the structures of some medications. Circle and identify functional groups the structures. H₂C H3C cole MDPV O Mephedrone Cocaine H CH3 CH3 CH3 CH3 Methylone H N CH3 CH3 Amphetamine CH3 NH₂ HO [18 HO HO Aco H OH 10-deacetylbaccatin III
Furosemide is a diuretic medication used to treat patients with congestive heart failure (CHF). It can treat fluid retention caused by CHF, liver disease or kidney failure. Please refer to the structure of Furosemide drawn below to answer the next five questions
Draw the structure of caffeine, acetaminophen, acetyl salicylic acid, and ibuprofen. Order them from most polar to least polar.
Please answer #7 and 8
1. Draw the chemical structures of both Amiodarone and Levothyroxine. Label all of the organic chemical reactions between them (you can use arrows, etc to do this). Aswell as explain Goitre in your own words, the increased iodine from the Amiodarone and why TSH may increase and T3, T4 remain normal etc. -0-CH2 -CH2-N Amiodarone C;H5 CH2)3 CH3 но NH2 Levothyroxine HO. HO. ÑH2
- A A Aa v A m、m、iv三E O Find - 三三三三m。 v田v Normal No Spacing Heading 1 x' A 2. A v Replace Dictate A Select v Paragraph Styles Editing Voice 19. Which of the following compounds will undergo oxidation using potassium dichromate to form a carboxylic acid? B a. A and B only с. В only b. A and C only d. C only 20. The reaction of which combination of reactants result in the formation of a hemiacetal? a. aldehyde and alcohol c. aldehyde and carboxylic acid b. aldehyde and amine d. aldehyde and water 21. Which of the following is true of hemiacetals? a. The most stable hemiacetals are noncyclic. b. The most stable hemiacetals have four- or five-membered rings. c. The most stable hemiacetals have five- or six-membered rings. d. The most stable hemiacetals contain no OH groups. 22. Which type of biologically important molecules includes many cyclic hemiacetals? a. carbohydrates c. Proteins b. lipids d. none of these * Accessibility: Investigate D'Focus 当 prt sc F10 home end F3 F4 F5 F6 F7 F8…
an ar- 10 Following is a structural formula for aspartame, a tificial sweetener about 180 times as sweet as sucrose (table sugar). -0 O Phenobarbital NH3 + O IZ Aspartame O OCH 3 HO HOOD A HO (d) Would you expect aspartame to be soluble in water? Explain. (Chapter 5) (e) Draw structural formulas for the products of com- plete hydrolysis of aspartame in aqueous HCl. Show each product as it would be ionized in this nedi 15. solution.
Can anyone help with these?
Draw the product for the following hydrolysis.
please please answer41 and 42
Answer the following :(i) Why is the use of aspartame limited to cold foods and drinks?(ii) How do antiseptics differ from disinfectants?(iii) Why do soaps not work in hard water?
QUESTION 27 Explain how you would apply the principles of rigidification to the structure below in order to improve its pharmacological properties. Give two specific examples of rigidified structures. gutor CH3

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Using the principles of soft-drugs, design a short acting version of sildenafil. You must draw your structure in the hand-in sheet. ΗΝ N