Using a Grignard reaction, show how you could prepare the following alcohol. OH Select the reactants needed (you can assume there will be an aqueous workup). 0 CH3MgBr H H H MgBr MgBr OH

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### Preparing Alcohol Using a Grignard Reaction

In this tutorial, we will show how you can prepare the following alcohol using a Grignard reaction:

![Hexyl alcohol structure](paste_structure_of_hexanol_here)

#### Select the Reactants Needed:

You can assume there will be an aqueous workup.

1. **Reactant Options:**
   - ![Option 1](paste_structure_here)
   - ![Option 2](paste_structure_here) - Cyclopentylmagnesiumbromide (Grignard reagent)
   - ![Option 3](paste_structure_here) - Cyclohexanone (Target molecule carbonyl precursor)
   - ![Option 4](paste_structure_here)
   - ![Option 5](paste_structure_here)
   - ![Option 6](paste_structure_here) - Formaldehyde (for primary alcohol without extra carbon chain)
   - ![Option 7](paste_structure_here) - The target alcohol (output not a precursor)
   
### Explanation of the Correct Reactants:
To synthesize the target alcohol (1-hexanol), we need a carbonyl compound and a Grignard reagent. 

- **Cyclohexanone** provides the necessary carbonyl group.
- **Cyclopentylmagnesiumbromide** is the Grignard reagent that will add the necessary carbon chain in a reaction with cyclohexanone.

The reaction follows these steps:
1. The nucleophilic carbon atom in the Grignard reagent (cyclopentylmagnesium bromide) attacks the electrophilic carbon in the carbonyl group of cyclohexanone.
2. This forms an alkoxide intermediate.
3. In the aqueous workup, the alkoxide is protonated to give the final alcohol product.

Thus, the needed reactants for this Grignard reaction are **Cyclopentylmagnesiumbromide** and **Cyclohexanone**.
Transcribed Image Text:### Preparing Alcohol Using a Grignard Reaction In this tutorial, we will show how you can prepare the following alcohol using a Grignard reaction: ![Hexyl alcohol structure](paste_structure_of_hexanol_here) #### Select the Reactants Needed: You can assume there will be an aqueous workup. 1. **Reactant Options:** - ![Option 1](paste_structure_here) - ![Option 2](paste_structure_here) - Cyclopentylmagnesiumbromide (Grignard reagent) - ![Option 3](paste_structure_here) - Cyclohexanone (Target molecule carbonyl precursor) - ![Option 4](paste_structure_here) - ![Option 5](paste_structure_here) - ![Option 6](paste_structure_here) - Formaldehyde (for primary alcohol without extra carbon chain) - ![Option 7](paste_structure_here) - The target alcohol (output not a precursor) ### Explanation of the Correct Reactants: To synthesize the target alcohol (1-hexanol), we need a carbonyl compound and a Grignard reagent. - **Cyclohexanone** provides the necessary carbonyl group. - **Cyclopentylmagnesiumbromide** is the Grignard reagent that will add the necessary carbon chain in a reaction with cyclohexanone. The reaction follows these steps: 1. The nucleophilic carbon atom in the Grignard reagent (cyclopentylmagnesium bromide) attacks the electrophilic carbon in the carbonyl group of cyclohexanone. 2. This forms an alkoxide intermediate. 3. In the aqueous workup, the alkoxide is protonated to give the final alcohol product. Thus, the needed reactants for this Grignard reaction are **Cyclopentylmagnesiumbromide** and **Cyclohexanone**.
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