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Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina does not have CF, but otherwise her family history is unknown. A) What is the probability that Tony is heterozygous for the CF gene? B) If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina's child will have CF?

Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina does not have CF, but otherwise her family history is unknown. A) What is the probability that Tony is heterozygous for the CF gene? B) If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina's child will have CF?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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**CF Genetics Problem Set** **Problem Statement:** Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina does not have CF, but otherwise her family history is unknown. **Question A:** What is the probability that Tony is heterozygous for the CF gene? **Question B:** If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina’s child will have CF? **Instructions for Answering:** To solve these questions, students need to understand the basics of genetic inheritance, particularly autosomal recessive disorders like Cystic Fibrosis (CF). - **Step 1:** Determine the probability that Tony is a carrier (heterozygous) for CF. - **Step 2:** Use the heterozygote frequency to determine the probability that Tina is a carrier. - **Step 3:** Calculate the combined probability that their child will inherit CF. Refer to the relevant genetic theories and Punnett squares for detailed step-by-step solutions. For a deeper understanding and thorough calculations, students might need to review concepts such as: - **Autosomal recessive inheritance patterns** - **Carrier probabilities and genetic risk assessments** Make sure to cover these points when explaining your methods and answers.
Transcribed Image Text:**CF Genetics Problem Set** **Problem Statement:** Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina does not have CF, but otherwise her family history is unknown. **Question A:** What is the probability that Tony is heterozygous for the CF gene? **Question B:** If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina’s child will have CF? **Instructions for Answering:** To solve these questions, students need to understand the basics of genetic inheritance, particularly autosomal recessive disorders like Cystic Fibrosis (CF). - **Step 1:** Determine the probability that Tony is a carrier (heterozygous) for CF. - **Step 2:** Use the heterozygote frequency to determine the probability that Tina is a carrier. - **Step 3:** Calculate the combined probability that their child will inherit CF. Refer to the relevant genetic theories and Punnett squares for detailed step-by-step solutions. For a deeper understanding and thorough calculations, students might need to review concepts such as: - **Autosomal recessive inheritance patterns** - **Carrier probabilities and genetic risk assessments** Make sure to cover these points when explaining your methods and answers.
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