THEME 3: In Drosophila recessive mutants called a, b, c, and d all have the same phenotype; namely, the absence of red pigment in the eyes. In pairwise crosses of homozygote mutants, each for a single gene, the results shown in the table below were produced. Please note that += wild-type phenotype (red eyes) and - = mutant phenotype (no eye pigment, white eyes). Please use the notation a+, b+, c+ and d+ to indicate wild-type alleles and a-, b-, c-, and d- for mutant alleles when describing genotypes. d с b a a + b + + - + - cd + a) What are the genotypes associated with the parents of the cross between mutant c and d? What is the genotype associated with the wild- type phenotype of the offspring? Parent genotypes Offspring genotype b) Which mutants have defects in the same gene? c) Through which genetic interaction is the offspring of some mutant crosses recovering the wild-type phenotype?

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**THEME 3: In Drosophila, recessive mutants called a, b, c, and d all have the same phenotype; namely, the absence of red pigment in the eyes.**

In pairwise crosses of homozygote mutants, each for a single gene, the results shown in the table below were produced.

Please note that:
- **+** = wild-type phenotype (red eyes)
- **−** = mutant phenotype (no eye pigment, white eyes).

Please use the notation a+, b+, c+, and d+ to indicate wild-type alleles and a−, b−, c−, and d− for mutant alleles when describing genotypes.

**Table Explanation:**

The table shows the results of pairwise crosses between the homozygote mutants (a, b, c, and d):

|     | a   | b   | c   | d   |
|-----|-----|-----|-----|-----|
| d   | -   | +   | +   | -   |
| c   | +   | +   | -   |     |
| b   | -   | -   |     |     |
| a   | -   |     |     |     |

The symbols in the cells indicate the phenotype of the offspring resulting from the cross:
- **"+" (wild-type phenotype):** red eyes
- **"−" (mutant phenotype):** no eye pigment, white eyes

**Questions:**

a) *What are the genotypes associated with the parents of the cross between mutant c and d? What is the genotype associated with the wild-type phenotype of the offspring?*

   Parent genotypes: [c−, d−]
   
   Offspring genotype: [c+, d+]

b) *Which mutants have defects in the same gene?*
   
   [b, a]

c) *Through which genetic interaction is the offspring of some mutant crosses recovering the wild-type phenotype?*

   [Complementation]
Transcribed Image Text:**THEME 3: In Drosophila, recessive mutants called a, b, c, and d all have the same phenotype; namely, the absence of red pigment in the eyes.** In pairwise crosses of homozygote mutants, each for a single gene, the results shown in the table below were produced. Please note that: - **+** = wild-type phenotype (red eyes) - **−** = mutant phenotype (no eye pigment, white eyes). Please use the notation a+, b+, c+, and d+ to indicate wild-type alleles and a−, b−, c−, and d− for mutant alleles when describing genotypes. **Table Explanation:** The table shows the results of pairwise crosses between the homozygote mutants (a, b, c, and d): | | a | b | c | d | |-----|-----|-----|-----|-----| | d | - | + | + | - | | c | + | + | - | | | b | - | - | | | | a | - | | | | The symbols in the cells indicate the phenotype of the offspring resulting from the cross: - **"+" (wild-type phenotype):** red eyes - **"−" (mutant phenotype):** no eye pigment, white eyes **Questions:** a) *What are the genotypes associated with the parents of the cross between mutant c and d? What is the genotype associated with the wild-type phenotype of the offspring?* Parent genotypes: [c−, d−] Offspring genotype: [c+, d+] b) *Which mutants have defects in the same gene?* [b, a] c) *Through which genetic interaction is the offspring of some mutant crosses recovering the wild-type phenotype?* [Complementation]
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