The second confirmed case was not documented until over a month later (Feb 28). The remarkable thing was that the genome of the virus isolated from the second patient was identical to that of the first person, except it had three additional mutations that were also not present in any isolates from the Wuhan region. With your knowledge of the mutation rate, how do you interpret the results?
The first case of COVID-19 in the US occurred in the state of Washington on Jan 24 and was diagnosed in a traveler that returned from the initial epicenter of the outbreak (Wuhan, China) on Jan 15. The sequence of the genome was identical to isolates from China, confirming the origin of the virus (as in the phylogeny above). The original patient was quarantined to stop the further spread of the virus. The second confirmed case was not documented until over a month later (Feb 28). The remarkable thing was that the genome of the virus isolated from the second patient was identical to that of the first person, except it had three additional mutations that were also not present in any isolates from the Wuhan region.
With your knowledge of the mutation rate, how do you interpret the results?
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