briefly describe four explanations why E. coli phages can only infect E. coli cells, but not other bacteria or human cells.

Human Anatomy & Physiology (11th Edition)
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**Topic: Specificity of E. coli Phages**

In this section, we will briefly describe four explanations for why *E. coli* phages are specific to infecting *E. coli* cells and do not target other bacteria or human cells.

1. **Host Receptor Recognition**: Phages have specific proteins that recognize and attach to receptors on the *E. coli* cell surface. These receptors are unique to *E. coli*, preventing the phage from binding to other bacteria or human cells.

2. **Genetic Compatibility**: The genetic material of the phage is compatible with *E. coli* cellular machinery, allowing successful replication of the phage genome within the host. This compatibility is often absent in other types of cells.

3. **Immune Evasion**: *E. coli* phages have evolved mechanisms to evade the bacterial defense systems specific to *E. coli*. Other bacteria or human cells might possess different defense strategies that the phage cannot overcome.

4. **Environmental Adaptation**: Over time, phages have adapted to utilize the nutrients and conditions presented by the *E. coli* cellular environment, which may not be present in other bacterial or human cells, thus preventing effective infection.

This specificity highlights the intricate evolutionary relationship between phages and their host bacteria.
Transcribed Image Text:**Topic: Specificity of E. coli Phages** In this section, we will briefly describe four explanations for why *E. coli* phages are specific to infecting *E. coli* cells and do not target other bacteria or human cells. 1. **Host Receptor Recognition**: Phages have specific proteins that recognize and attach to receptors on the *E. coli* cell surface. These receptors are unique to *E. coli*, preventing the phage from binding to other bacteria or human cells. 2. **Genetic Compatibility**: The genetic material of the phage is compatible with *E. coli* cellular machinery, allowing successful replication of the phage genome within the host. This compatibility is often absent in other types of cells. 3. **Immune Evasion**: *E. coli* phages have evolved mechanisms to evade the bacterial defense systems specific to *E. coli*. Other bacteria or human cells might possess different defense strategies that the phage cannot overcome. 4. **Environmental Adaptation**: Over time, phages have adapted to utilize the nutrients and conditions presented by the *E. coli* cellular environment, which may not be present in other bacterial or human cells, thus preventing effective infection. This specificity highlights the intricate evolutionary relationship between phages and their host bacteria.
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