The pathophysiology of chronic diabetic complications is related to which process? Question 65 options: a)  Oxidative stress and ROS have a limited role in the pathophysiology of diabetes mellitus b)  Sorbitol and fructose are products of the polyol pathway that accumulate and reduce intracellular osmotic pressure causing cellular injury c)  AGEs are formed by the irreversible binding of glucose to proteins, lipids and nucleic acids d)  The hexosamine pathway causes pathologic changes in gene expression associated with increased insulin activity and improved cardiovascular health

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