The mouse facility sends you the wrongknockout mice. For fun, you check levels ofcholesterol and cholesterol precursors in themice and find that the mice you mistakenlyreceived have very low levels of cholesterol(similar to the case of dhcr7 (-/-) mice).These mice however have elevated levels ofsqualene in their serum and tissues. Theenzymes in the pathway have beennumbered for your convenience in theschematic below. Which enzyme number(enzyme 1-5) do you think is mutated in theknockout mouse you received? In one briefsentence, explain why you chose thatenzyme.Geranyl-PPEnzyme 1 -Farnesyl-PPEnzyme 2SqualeneEnzyme 3LanosterolEnzyme 47-DehydrocholesterolEnzyme 5 -Cholesterol

Knockout mice are created in the laboratory in which one or more genes have been deleted. Such mice…

Answered: The mouse facility sends you the wrong…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Geneticists are studying a malfunctioning protein that causes impaired endothelial cell migration and angiogenesis. They have noticed that the amino acid sequence of the protein is truncated compared to normal controls. The mutated mRNA strand is isolated, and analysis shows a nonsense mutation located near the 3' end of the coding region. The 3' terminal coding sequence of the abnormal mRNA strand is shown below. 5`- AUG-ACC-ACU-CCA-CUG-UUG-UUC-CAA-GGG-GAG-AGC-UAG-GUC-CGG-GGC-GGA-AAA-UUU-UAA-3` Write down the tRNA anticodon responsible for adding the last amino acid?
What would happen if you changed the anticodon in the Tryptophan tRNA from ACC to AAC? First letter U C A G U UUU Phe UUC Phe UUA Leu UUG Leu CỰU Leu CUC Leu CUA Leu CUG Leu AUU lle AUC lle AUA lle AUG Met GUU Val GUC Val GUA Val GUG Val Second letter C A UCU Ser UCC Ser UCA Ser UCG Ser CCU Pro CCC Pro CCA Pro CCG Pro ACU Thr ACC Thr ACA Thr ACG Thr GCU Ala GCC Ala GCA Ala GCG Ala UAU Tyr UAC Tyr UAA Stop UAG Stop CAU His CAC His CAA Gln CAG Gln AAU Asn AAC Asn AAA Lys AAG Lys GAU Asp GAC Asp GAA Glu GAG Glu G UGU Cys UGC Cys UGA Stop UGG Trp CGU Arg CGC Arg CGA Arg CGG Arg AGU Ser AGC Ser AGA Arg AGG Arg GGU Gly GGC Gly GGA Gly GGG Gly O Tryptophan would be incorporated into peptides where leucine normally goes Tryptophan would be incorporated into peptides where it normally goes ○ Leucine would be incorporated into peptides where Tryptophan normally goes O Histidine would be incorporated into peptides where Leucine normally goes U C A G U C A G U C A G U C A G Third letter
Which statement(s) describe the function of the protein encoded by KMT2D ? Transcription factor involved in the DNA damage response. A component of haemoglobin. A subunit of - secreatase. An enzyme invovled in nucleotide biosynthesis. An enzyme involved in the breakdown of glycosaminoglycans (GAGS). Involved in fat and muscle cell differentiation A cell surface protein involved in iron absorption.
You are given 3 tubes of RNA and asked by your supervisor to clone the gene encoding the proinsulin C-peptide that will be used later to produce insulin. The first tube contains purified mRNA isolated from pancreatic B-cells from a patient in a post-absorptive state. The second tube contains purified MRNA isolated from pancreatic a-cells from a patient during absorptive state. The third tube contains purified MRNA isolated from pancreatic B-cells from a patient during absorptive state. In not more than 2 pages (using 1.5 line space of Arial or Times New Roman fonts) provide answers for the following questions? 1) Which tube from the three is the most appropriate to use and why? 2) Describe the primary procedure (key steps no details) that you will follow to clone the C-peptide gene from the RNA above into the only vector you have, a pUC expression vector cut open using EcoR1 which has a 5'-recognition site and a 3'- HindlII in the MCS? 3) How can you guarantee a high expression of your…
TRNAS do vary in length. True False
One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain and other severe complications. What is the name of the process in which each peptide is actually assembled, and where does this process take place? transcription, on ribosomes translation, in the nucleus translation, on ribosomes transcription, in the nucleus
The genetic code is redundant (i.e., most amino acids are coded for by more than one codon). Why is this beneficial when it comes to errors in DNA replication or transcription?
The following diagram represents one of the Christmas-tree-like structures shown in Figure On the diagram, identify parts a through i. Q. Molecules of RNA polymerase (use dots to represent these molecules)
Beadle and Tatum's experiments led to the "one gene - one enzyme (protein)" hypothesis. In subsequent years, many exceptions to this hypothesis were noted. A molecule of hemoglobin fails to support this hypothesis for which of the following reasons? n eukaryotes, one gene can code form multiple isoforms of a polypeptide. The functional hemoglobin protein is made from multiple polypeptides. Not all enzymes are proteins. Not all genes encode proteins.
Jack is applyng to Gate's foundation for a grant to make a high affinity, humanized monoclonal antibody that could neutralize venom, a 7 kDa protein of 62 amino aicds, from cobra snakes. He argues that many people in tropical areas are bitten by the poisonous snakes and may need injection of this life-saving anitbody more than once. His friend has successfully purified the 7kDA venom protein expressed in E. coli in a large quantity and will give him whatever he needs for his project. Among more than 100 candidates, what can he do to identify those that recognize the venom?
TRUE OR FALSE: tRNA-met complexes with mRNA at the aminoacyl-site of the ribosome
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The mouse facility sends you the wrong knockout mice. For fun, you check levels of cholesterol and cholesterol precursors in the mice and find that the mice you mistakenly