The mother of a family with 10 children has blood typeRh+. She also has a very rare condition (elliptocytosis,phenotype E) that causes red blood cells to be oval rather than round in shape but that produces no adverseclinical effects. The father is Rh− (lacks the Rh+ antigen)and has normal red blood cells (phenotype e). The children are 1 Rh+ e, 4 Rh+ E, and 5 Rh− e. Information isavailable on the mother’s parents, who are Rh+ E andRh− e. One of the 10 children (who is Rh+ E) marriessomeone who is Rh+ e, and they have an Rh+ E child.a. Draw the pedigree of this whole family.b. Is the pedigree in agreement with the hypothesisthat the Rh+ allele is dominant and Rh− is recessive?c. What is the mechanism of transmission ofelliptocytosis?d. Could the genes governing the E and Rh phenotypesbe on the same chromosome? If so, estimate the mapdistance between them, and comment on your result
The mother of a family with 10 children has blood type
Rh+. She also has a very rare condition (elliptocytosis,
phenotype E) that causes red blood cells to be oval rather than round in shape but that produces no adverse
clinical effects. The father is Rh− (lacks the Rh+ antigen)
and has normal red blood cells (phenotype e). The children are 1 Rh+ e, 4 Rh+ E, and 5 Rh− e. Information is
available on the mother’s parents, who are Rh+ E and
Rh− e. One of the 10 children (who is Rh+ E) marries
someone who is Rh+ e, and they have an Rh+ E child.
a. Draw the pedigree of this whole family.
b. Is the pedigree in agreement with the hypothesis
that the Rh+ allele is dominant and Rh− is recessive?
c. What is the mechanism of transmission of
elliptocytosis?
d. Could the genes governing the E and Rh
be on the same chromosome? If so, estimate the map
distance between them, and comment on your result
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