The genetic map shows the location of three genes on a chromosome. Order the gene pairs based on their likelihood of recombining from most likely to least likely to recombine. Most likely genes A and C A genes A and B В genes B and C Least likely C Answer Bank Incorrect
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- A colleague e-mails you saying that she has identified an interesting chromosome variation at 21q13. In discussing this discovery with a friend who is not a cytogeneticist, explain how you would describe this location, defining each term in the chromosome address 21q13.Which letter is pointing at the centromere region? В A CThe maternal-effect mutation bicoid (bcd) is recessive. Inthe absence of the bicoid protein product, embryogenesis isnot completed. Consider a cross between a female heterozygousfor the bicoid mutation (bcd+/ bcd-) and a homozygousmale(bcd-/ bcd-). Predict the outcome (normal vs. failed embryogenesis) inthe F1 and F2 generations of the cross described.
- Referring to Figure 17-19, draw a diagram showing theprocess whereby an inversion formed from crossing overcould generate a normal sequence.A female fruit fly has one normal X chromosome and one X chromosomewith a deletion. The deletion occurred in the middle ofthe X chromosome and removed about 10% of the entire length ofthe X chromosome. Suppose you stained and observed the chromosomesin salivary gland cells of this female fruit fly. Draw thepolytene arm of the X chromosome. Explain your drawing.Describe when X-chromosome inactivation occurs and how thisleads to phenotypic results at the organism level. In your answer,you should explain why XCI causes results such as variegated coatpatterns in mammals. Why do two different calico cats have theirpatches of orange and black fur in different places? Explainwhether or not a variegated coat pattern due to XCI could occur inmarsupials.
- Mutations in DNA that result in altered proteins can causehereditary diseases. Pedigree studies and genetic testing mayclarify the risk of disease. At the chromosome level, nondisjunctionduring meiosis can result in gametes with too few or too manychromosomes, most of which produce inviable offspring.Imprinting refers to inactivation of alleles depending on whichparent the alleles come from; offspring in whom imprinting occursappear haploid for the affected gene even though they are diploid. During spermatogenesis, is there any difference in outcome between first- and second-division nondisjunction?The XG locus on the human X chromosome has twoalleles, XG+ and XG. The XG+ allele causes the presence of the Xg surface antigen on red blood cells,while the recessive XG allele does not allow antigento appear. The XG locus is 10 m.u. from the STSlocus. The STS+ allele produces normal activity ofthe enzyme steroid sulfatase, while the recessive STSallele results in the lack of steroid sulfatase activityand the disease ichthyosis (scaly skin). A man withichthyosis and no Xg antigen has a normal daughterwith Xg antigen. This daughter is expecting a child.a. If the child is a son, what is the probability he willlack Xg antigen and have ichthyosis?b. What is the probability that a son would have boththe antigen and ichthyosis?c. If the child is a son with ichthyosis, what is theprobability he will have Xg antigen?A somatic cell has the genotype DdEe. All chromosomes in this organism are metacentric. Show metaphase and the results of mitosis if the D and E locus are linked on the same chromosome in trans configuration. A sexually reproducing organism has the following phenotype DdEeAaTt: The D and E loci are on the same arm of a metacentric chromosome in cis configuration. The A locus is on the long arm of an acrocentric chromosome and the T locus is on a telocentric chromosome. 2.1. What is the haploid number of this organism? 2.2. Using diagrams show a ceii at metaphase of mitosis and show the results of mitosis.
- CIUSS O An organism has the genotype a g*/a"g*; qf"/q+f*;r+h+/rth*. Indicate the correct genes/ alleles at all the positions numbered 1-12 in the image below such that the diagram accurately represents the genotype of this organism. Note: assume the first chromosome in each pair shown in the genotype is the top chromosome shown in the diagram. 1 i 2: a gene g gene 6. q gene fgene 7 8. | 10 r gene h gene 12 Only place the genes/ alleles you need. You will not need them all. You may need to use some more than once. • gene / allele 1 a- ; gene / allele 2 g+ ; gene / allele 3 a- gene/allele 4 g++ • gene / allele 5 q- ; gene / allele 6 f- gene / allele 7 q+; gene / allele 8 f- gene / allele 9 r+; gene / allele 10 h+ gene / allele 11 r+ gene / allele 12 h+ a+ a- f+ f- g+ g- h+ h- q+ q- r+ r- 2.An inversion heterozygote has the following inverted chromosome: Centromere ca a a A B CD JI HGF E, KL M Inverted region If a crossover occurred between genes H and I on one inverted and one normal chromosome, what would be the sequence of the dicentric chromosome before completion of metaphase I? A Cen B C D EFGHIJKL Cen M A Cen B C D JIHGFEKLM Cen JIH G F E Cen A Cen B C D JIHGFEDC B Cen A MLKEFGHIJKLMChromosome structural errors can occur during Meiosis which can lead to health disorders. Examine the figure below and select the correct order of error type from left to right in which they appear. duplicati on, translocation, deleti on, inversion duplication, inversion, del etion, translocation O deletion, translocati on, inversion, duplication O translocation, inversion, duplication, deletion inversion, translocation, duplication, deletion