The following data represent the cumulative amount permeated of drug X, across excised rat skin, vs. time. If the surface area of the Franz diffusion cell is 0.636 cm², generate the transdermal permeation profile and calculate the following transdermal permeation parameters: J (transdermal permeation flux), P (permeability coefficient), tag (lag time), D/h² (diffusion coefficient) and Km.h (partition coefficient). Initial drug concentration in vehicle, Cs, is 1.29 mg/mL. Cumulative amount (ng) 0 20.95 78.88 240.58 471.31 777.55 Time (hr) 12 18 24 37 43 49 co 1315 6₁
The following data represent the cumulative amount permeated of drug X, across excised rat skin, vs. time. If the surface area of the Franz diffusion cell is 0.636 cm², generate the transdermal permeation profile and calculate the following transdermal permeation parameters: J (transdermal permeation flux), P (permeability coefficient), tag (lag time), D/h² (diffusion coefficient) and Km.h (partition coefficient). Initial drug concentration in vehicle, Cs, is 1.29 mg/mL. Cumulative amount (ng) 0 20.95 78.88 240.58 471.31 777.55 Time (hr) 12 18 24 37 43 49 co 1315 6₁
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:The following data represent the cumulative amount permeated of drug X, across excised rat skin, vs. time. If the surface
area of the Franz® diffusion cell is 0.636 cm², generate the transdermal permeation profile and calculate the following
transdermal permeation parameters: J (transdermal permeation flux), P (permeability coefficient), tug (lag time), D/h?
(diffusion coefficient) and Km.h (partition coefficient). Initial drug concentration in vehicle, Cs, is 1.29 mg/mL.
Time (hr)
Cumulative amount (ng)
12
18
20.95
24
78.88
37
240.58
43
471.31
49
777.55
60
1215.64
72
1735.76
- Slope of the linear portion of the plot corresponds to the transdermal permeation flux.
- P = J/Cs
- From extrapolation of the linear portion: tng
- D/h? = 1/ (6 tag)
- Km.h = P / (D/h²)
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