Ten patients with advanced diabetic nephropathy (kidney complications of diabetes) were treated with cap- topril over an 8-week period. Urinary protein was measured before and after drug therapy, with results lis- ted in Table 1 in both raw and In (natural log) scales. Table 1: Changes in urinary protein (in g/24 hr) after treatment with captopril Raw Scale In Scale Patient Before After Before After 1 25.6 10.1 3.24 2.31 2 17.0 5.7 2.83 1.74 3 16.0 5.6 2.77 1.72 4 10.4 3.4 2.34 1.22 5 8.2 6.5 2.10 1.87 6 7.9 0.7 2.07 -0.36 7 5.8 6.1 1.76 1.81 8 5.4 4.7 1.69 1.55 9 5.1 2.0 1.63 0.69 10 4.7 2.9 1.55 1.06 8. What is the appropriate statistical procedure to test whether mean urinary protein has changed over the 8-week period?

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Ten patients with advanced diabetic nephropathy (kidney complications of diabetes) were treated with cap-
topril over an 8-week period. Urinary protein was measured before and after drug therapy, with results lis-
ted in Table 1 in both raw and In (natural log) scales.
Table 1: Changes in urinary protein (in g/24 hr) after treatment with captopril
Raw Scale
In Scale
Patient
Before After
Before After
1
25.6
10.1
3.24
2.31
2
17.0
5.7
2.83
1.74
3
16.0
5.6
2.77
1.72
4
10.4
3.4
2.34
1.22
5
8.2
6.5
2.10
1.87
6
7.9
0.7
2.07 -0.36
7
5.8
6.1
1.76
1.81
8
5.4
4.7
1.69
1.55
9
5.1
2.0
1.63
0.69
10
4.7
2.9
1.55
1.06
8. What is the appropriate statistical procedure to test whether mean urinary protein has changed over
the 8-week period?
Transcribed Image Text:Ten patients with advanced diabetic nephropathy (kidney complications of diabetes) were treated with cap- topril over an 8-week period. Urinary protein was measured before and after drug therapy, with results lis- ted in Table 1 in both raw and In (natural log) scales. Table 1: Changes in urinary protein (in g/24 hr) after treatment with captopril Raw Scale In Scale Patient Before After Before After 1 25.6 10.1 3.24 2.31 2 17.0 5.7 2.83 1.74 3 16.0 5.6 2.77 1.72 4 10.4 3.4 2.34 1.22 5 8.2 6.5 2.10 1.87 6 7.9 0.7 2.07 -0.36 7 5.8 6.1 1.76 1.81 8 5.4 4.7 1.69 1.55 9 5.1 2.0 1.63 0.69 10 4.7 2.9 1.55 1.06 8. What is the appropriate statistical procedure to test whether mean urinary protein has changed over the 8-week period?
9. Perform the test in Problem 8 using both the raw and In scales, and report a p-value. Are there any
advantages to using the raw or the In scale?
Transcribed Image Text:9. Perform the test in Problem 8 using both the raw and In scales, and report a p-value. Are there any advantages to using the raw or the In scale?
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