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Table 2. Relative risks (RRS) and 95% confidence intervals (CIS) for second cancers after invasive breast cancer associated with body mass index (per 5 kg/m²), Kaiser Permanente Breast Cancer Survivors Cohort (1990-2017) Outcome All cancers Obesity-related cancers Breast cancers ER-positive breast cancers No. of cancers 822 508 333 231 Person-years 47 691 47 691 47 691 47 691 Unadjusted RR (95% CI) 1.05 (1.00 to 1.11) 1.09 (1.02 to 1.17) 1.09 (1.00 to 1.19) 1.12 (1.01 to 1.24) pb .06 .01 .046 .03 Adjusted" RR (95% CI) 1.07 (1.01 to 1.14) 1.13 (1.05 to 1.21) 1.11 (1.02 to 1.21) 1.15 (1.04 to 1.27) pb .01 <.001 .01 008 "Adjusted for study site, race and ethnicity, age, comorbidity index, receipt of radiation, receipt of chemotherapy, receipt of hormonal therapy, ER and PR status, stage, and year of initial breast cancer diagnosis. P values reflect 2-sided x² tests.

Table 2. Relative risks (RRS) and 95% confidence intervals (CIS) for second cancers after invasive breast cancer associated with body mass index (per 5 kg/m²), Kaiser Permanente Breast Cancer Survivors Cohort (1990-2017) Outcome All cancers Obesity-related cancers Breast cancers ER-positive breast cancers No. of cancers 822 508 333 231 Person-years 47 691 47 691 47 691 47 691 Unadjusted RR (95% CI) 1.05 (1.00 to 1.11) 1.09 (1.02 to 1.17) 1.09 (1.00 to 1.19) 1.12 (1.01 to 1.24) pb .06 .01 .046 .03 Adjusted" RR (95% CI) 1.07 (1.01 to 1.14) 1.13 (1.05 to 1.21) 1.11 (1.02 to 1.21) 1.15 (1.04 to 1.27) pb .01 <.001 .01 008 "Adjusted for study site, race and ethnicity, age, comorbidity index, receipt of radiation, receipt of chemotherapy, receipt of hormonal therapy, ER and PR status, stage, and year of initial breast cancer diagnosis. P values reflect 2-sided x² tests.

MATLAB: An Introduction with Applications
MATLAB: An Introduction with Applications
6th Edition
ISBN:9781119256830
Author:Amos Gilat
Publisher:Amos Gilat
Chapter1: Starting With Matlab
Section: Chapter Questions
Problem 1P
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1.Is the adjusted relationship between body mass index and ER-positive breast cancers statistically significant?  Give the reason for your answer in one short statement (no more than 10 words)

2. What is the most likely adjusted estimate for the RR for body mass index and ER-positive breast cancers?  (provide a numerical answer with 2 decimals) 

3. What is the highest plausible value for adjusted RR for body mass index and ER-positive breast cancers?   (provide a numerical answer with 2 decimals) 

4. If you were to calculate a Rate Difference for the relationship of body mass index and ER-positive breast cancers and test for statistical significance, what is your Null Hypothesis. 

Table 2. Relative risks (RRS) and 95% confidence intervals (CIS) for second cancers after invasive breast cancer associated with body mass index (per 5 kg/m²), Kaiser Permanente Breast Cancer Survivors Cohort (1990-2017) Outcome All cancers Obesity-related cancers Breast cancers ER-positive breast cancers No. of cancers 822 508 333 231 Person-years 47 691 47 691 47 691 47 691 Unadjusted RR (95% CI) 1.05 (1.00 to 1.11) 1.09 (1.02 to 1.17) 1.09 (1.00 to 1.19) 1.12 (1.01 to 1.24) pb .06 .01 .046 .03 Adjusted" RR (95% CI) 1.07 (1.01 to 1.14) 1.13 (1.05 to 1.21) 1.11 (1.02 to 1.21) 1.15 (1.04 to 1.27) .01 <.001 .01 .008 "Adjusted for study site, race and ethnicity, age, comorbidity index, receipt of radiation, receipt of chemotherapy, receipt of hormonal therapy, ER and PR status, stage, and year of initial breast cancer diagnosis. P values reflect 2-sided ² tests.
Transcribed Image Text:Table 2. Relative risks (RRS) and 95% confidence intervals (CIS) for second cancers after invasive breast cancer associated with body mass index (per 5 kg/m²), Kaiser Permanente Breast Cancer Survivors Cohort (1990-2017) Outcome All cancers Obesity-related cancers Breast cancers ER-positive breast cancers No. of cancers 822 508 333 231 Person-years 47 691 47 691 47 691 47 691 Unadjusted RR (95% CI) 1.05 (1.00 to 1.11) 1.09 (1.02 to 1.17) 1.09 (1.00 to 1.19) 1.12 (1.01 to 1.24) pb .06 .01 .046 .03 Adjusted" RR (95% CI) 1.07 (1.01 to 1.14) 1.13 (1.05 to 1.21) 1.11 (1.02 to 1.21) 1.15 (1.04 to 1.27) .01 <.001 .01 .008 "Adjusted for study site, race and ethnicity, age, comorbidity index, receipt of radiation, receipt of chemotherapy, receipt of hormonal therapy, ER and PR status, stage, and year of initial breast cancer diagnosis. P values reflect 2-sided ² tests.
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