Synthesis is ALWAYS in the 5-3 directión What happens if a base mismatch occurs? Where does energy for addition of nucleotide come from? 3' end of strand DNA polymerase 5' end of strand template DNA strand 5 CEG 3'3

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Please help me explain this on my report on cell dogma 

In what direction does DNA replication occur?
C) Synthesis is ALWAYS in the 5’-3’ direction
What happens if a base
mismatch occurs?
Where does energy for addition
of nucleotide come from?
3' end of strand
DNA polymerase
5' end of strand
template
DNA strand
"o-P-o
3
Op-o
POLYMERASE ADDS AN
INCORRECT NUCLEOTIDE
primer
strand
template
strand
5
OP-O
3'
OO O 05'
MISPAIRED NUCLEOTIDE
OH
3' end of
strand
-0-CH
REMOVED BY 3'- 5' PROOFREADING
pyrophosphate
он
A
CORRECTLY PAIRED 3' END ALLOWS
ADDITION OF NEXT NUCLEOTIDE
O-o
incoming
deoxyribonucleoside
triphosphate
5'
SYNTHESIS CONTINUES IN
THE 5'- 3' DIRECTION
5' end of strand
2004 Garland Science)
sential Cell Biology, 2/e. (O 2004 Garland Science)
Transcribed Image Text:In what direction does DNA replication occur? C) Synthesis is ALWAYS in the 5’-3’ direction What happens if a base mismatch occurs? Where does energy for addition of nucleotide come from? 3' end of strand DNA polymerase 5' end of strand template DNA strand "o-P-o 3 Op-o POLYMERASE ADDS AN INCORRECT NUCLEOTIDE primer strand template strand 5 OP-O 3' OO O 05' MISPAIRED NUCLEOTIDE OH 3' end of strand -0-CH REMOVED BY 3'- 5' PROOFREADING pyrophosphate он A CORRECTLY PAIRED 3' END ALLOWS ADDITION OF NEXT NUCLEOTIDE O-o incoming deoxyribonucleoside triphosphate 5' SYNTHESIS CONTINUES IN THE 5'- 3' DIRECTION 5' end of strand 2004 Garland Science) sential Cell Biology, 2/e. (O 2004 Garland Science)
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