Answered: Sydney Brenner isolated Salmonella…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Sydney Brenner isolated Salmonella typhimurium mutants that were
implicated in the biosynthesis of tryptophan and would not grow on
minimal medium. When these bacterial mutants were tested on minimal
medium to which one of four compounds (indole glycerol phosphate,
indole, anthranilic acid, and tryptophan) had been added, the growth
responses shown in the following table were obtained.
Mutant Minimal
medium
Anthranilic
acid
Indole glycerol
phosphate Indole Tryptophan
trp-1 − − − − +
trp-2 − − + + +
trp-3 − − − + +
trp-4 − − + + +
trp-6 − − − − +
trp-7 − − − − +
trp-8 − + − − +
trp-9 − − − − +
trp-10 − − − − +
trp-11 − − − − +
Give the order of indole glycerol phosphate, indole, anthranilic acid, and
tryptophan in a biochemical pathway leading to the synthesis of
tryptophan. Indicate which step in the pathway is affected by each of the
mutations.

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