Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to make E. Which one of these methods is preferred, and why? Be sure to answer all parts. Part 1: CH3I Method [1]: Method [2]: Part 2: A B NaOCH3 B + C D + AV CH3OH THF D ONa E E E OCH 3 Which one of these methods is preferred, and why? Method [2] is preferred because the less substituted alkyl halide results in a more stable carbocation. Method [1] is preferred because the alkyl halide should be relatively hindered in an SN2 reaction mechanism. Method [2] is preferred because the alkyl halide should be unhindered in an S№2 reaction mechanism. Method [1] is preferred because the more substituted alkyl halide results in a more stable carbocation.
Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to make E. Which one of these methods is preferred, and why? Be sure to answer all parts. Part 1: CH3I Method [1]: Method [2]: Part 2: A B NaOCH3 B + C D + AV CH3OH THF D ONa E E E OCH 3 Which one of these methods is preferred, and why? Method [2] is preferred because the less substituted alkyl halide results in a more stable carbocation. Method [1] is preferred because the alkyl halide should be relatively hindered in an SN2 reaction mechanism. Method [2] is preferred because the alkyl halide should be unhindered in an S№2 reaction mechanism. Method [1] is preferred because the more substituted alkyl halide results in a more stable carbocation.
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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![**Title: Reaction Pathway Selection for Synthesizing Compound E**
**Introduction:**
Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to make E. Which one of these methods is preferred, and why? Be sure to answer all parts.
**Compounds:**
- A: CH₃I
- B: Cyclohexyl iodide
- C: Sodium methoxide (NaOCH₃)
- D: Sodium cyclohexoxide (ONa)
- E: Cyclohexyl methyl ether (OCH₃)
**Part 1: Reaction Methods**
**Method [1]:**
- **Reaction:** B + C → E
- **Solvent:** CH₃OH (Methanol)
**Method [2]:**
- **Reaction:** D + A → E
- **Solvent:** THF (Tetrahydrofuran)
**Part 2: Preferred Method**
**Question: Which one of these methods is preferred, and why?**
- **Option 1:** Method [2] is preferred because the less substituted alkyl halide results in a more stable carbocation.
- **Option 2:** Method [1] is preferred because the alkyl halide should be relatively hindered in an Sₙ2 reaction mechanism.
- **Option 3:** Method [2] is preferred because the alkyl halide should be unhindered in an Sₙ2 reaction mechanism.
- **Option 4:** Method [1] is preferred because the more substituted alkyl halide results in a more stable carbocation.
**Preferred Answer:**
- **Method [2] is preferred because the alkyl halide should be unhindered in an Sₙ2 reaction mechanism.**
This conclusion emphasizes the advantage of using an unhindered alkyl halide in facilitating the bimolecular nucleophilic substitution (Sₙ2) mechanism, which is known for favoring primary or unhindered substrates.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa8ba3a71-d749-40cb-a922-6232b6a4906b%2F6f7d27a0-e3ed-4b79-aaac-48411660e205%2Fkltdit7_processed.jpeg&w=3840&q=75)
Transcribed Image Text:**Title: Reaction Pathway Selection for Synthesizing Compound E**
**Introduction:**
Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to make E. Which one of these methods is preferred, and why? Be sure to answer all parts.
**Compounds:**
- A: CH₃I
- B: Cyclohexyl iodide
- C: Sodium methoxide (NaOCH₃)
- D: Sodium cyclohexoxide (ONa)
- E: Cyclohexyl methyl ether (OCH₃)
**Part 1: Reaction Methods**
**Method [1]:**
- **Reaction:** B + C → E
- **Solvent:** CH₃OH (Methanol)
**Method [2]:**
- **Reaction:** D + A → E
- **Solvent:** THF (Tetrahydrofuran)
**Part 2: Preferred Method**
**Question: Which one of these methods is preferred, and why?**
- **Option 1:** Method [2] is preferred because the less substituted alkyl halide results in a more stable carbocation.
- **Option 2:** Method [1] is preferred because the alkyl halide should be relatively hindered in an Sₙ2 reaction mechanism.
- **Option 3:** Method [2] is preferred because the alkyl halide should be unhindered in an Sₙ2 reaction mechanism.
- **Option 4:** Method [1] is preferred because the more substituted alkyl halide results in a more stable carbocation.
**Preferred Answer:**
- **Method [2] is preferred because the alkyl halide should be unhindered in an Sₙ2 reaction mechanism.**
This conclusion emphasizes the advantage of using an unhindered alkyl halide in facilitating the bimolecular nucleophilic substitution (Sₙ2) mechanism, which is known for favoring primary or unhindered substrates.
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