Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to make E. Which one of these methods is preferred, and why? Be sure to answer all parts. Part 1: CH3I Method [1]: Method [2]: Part 2: A B NaOCH3 B + C D + AV CH3OH THF D ONa E E E OCH 3 Which one of these methods is preferred, and why? Method [2] is preferred because the less substituted alkyl halide results in a more stable carbocation. Method [1] is preferred because the alkyl halide should be relatively hindered in an SN2 reaction mechanism. Method [2] is preferred because the alkyl halide should be unhindered in an S№2 reaction mechanism. Method [1] is preferred because the more substituted alkyl halide results in a more stable carbocation.

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to
make E. Which one of these methods is preferred, and why? Be sure to answer all parts.
Part 1:
CH3I
Method [1]:
Method [2]:
Part 2:
A
B
NaOCH 3
B + CV
D + Av
CH3OH
THF
D
ONa
E
E
E
OCH3
Which one of these methods is preferred, and why?
Method [2] is preferred because the less substituted alkyl halide results in a more stable
carbocation.
Method [1] is preferred because the alkyl halide should be relatively hindered in an SÃ2
reaction mechanism.
Method [2] is preferred because the alkyl halide should be unhindered in an SÃ2 reaction
mechanism.
Method [1] is preferred because the more substituted alkyl halide results in a more stable
carbocation.
Transcribed Image Text:Suppose you have compounds A-D at your disposal. Using these compounds, devise two different ways to make E. Which one of these methods is preferred, and why? Be sure to answer all parts. Part 1: CH3I Method [1]: Method [2]: Part 2: A B NaOCH 3 B + CV D + Av CH3OH THF D ONa E E E OCH3 Which one of these methods is preferred, and why? Method [2] is preferred because the less substituted alkyl halide results in a more stable carbocation. Method [1] is preferred because the alkyl halide should be relatively hindered in an SÃ2 reaction mechanism. Method [2] is preferred because the alkyl halide should be unhindered in an SÃ2 reaction mechanism. Method [1] is preferred because the more substituted alkyl halide results in a more stable carbocation.
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