state the most common reason for a false-negative antibody test
state the most common reason for a false-negative antibody test
Explanation:
False negative test is the negative result obtained due to negative reaction in the testing sample.
Principle of antibody test: Recombinant antigen which are produced in the laboratory and are specifically designed to mimic specific structures of the target virus particles, during testing the principle of the test will be that any antibodies present in whole blood or serum with a binding affinity to attach to the antigen will react with the antigen specifically to form antigen-antibody complexes, making a positive result.
So, its clear that in a negative result there is no reaction of the recombinant antigen and the antibodies that develop against it.
When the foreign particle has infected the system, body will produce antibody against the antigen that attacked so there will be a logarithmic increase owing to the clonal propagation of the B cells having the specific antibodies for the foreign antigen. So at start the selection of the specific antibody containing b cells happen and then the clonal propagation starts so a minimum amount of antibody needs to be there in the test sample for it to react with the antigen raised against it and give a positive reaction. if too less antibody molecules are there then that is marked negative considering it as a disturbance or side reaction.
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