Specify the reagent you would use in each step of the following synthesis: H step 1 step 2 Reagents Available a. LIAIH4 f. PBr3 k. CH3CH₂MgBr b. H₂SO4 g. Dess-Martin periodinane (DMP) 1. C6H5MgBr (phenylmagnesium bromide) c. HCI h. NaH m. (CH3)2CHMgBr d. HBr i. NaOH n. CrO3 e. SOCI2 j. CH₂MgBr Write the letters of the reagents in the boxes below. Reagent for step 1 Reagent for step 2
Specify the reagent you would use in each step of the following synthesis: H step 1 step 2 Reagents Available a. LIAIH4 f. PBr3 k. CH3CH₂MgBr b. H₂SO4 g. Dess-Martin periodinane (DMP) 1. C6H5MgBr (phenylmagnesium bromide) c. HCI h. NaH m. (CH3)2CHMgBr d. HBr i. NaOH n. CrO3 e. SOCI2 j. CH₂MgBr Write the letters of the reagents in the boxes below. Reagent for step 1 Reagent for step 2
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![## Synthesis Problem Exercise
### Objective:
Specify the reagent you would use in each step of the following synthesis:
### Reaction Scheme:
The diagram depicts a two-step synthesis starting with a benzaldehyde (structure with a benzene ring attached to a formyl group (—CHO)).
1. **Step 1**: The formyl group (—CHO) on the benzene ring is transformed to an acid chloride group (—COCl).
2. **Step 2**: The acid chloride group (—COCl) is further reacted to form a compound with a benzene ring attached to a trans-styrene group (—CH=CH—C6H5).
### Reagents Available:
A list of letters (a to n) corresponding to different chemical reagents are provided:
- a. LiAlH4
- b. H2SO4
- c. HCl
- d. HBr
- e. SOCl2
- f. PBr3
- g. Dess-Martin periodinane (DMP)
- h. NaH
- i. NaOH
- j. CH3MgBr
- k. CH3CH2MgBr
- l. C6H5MgBr (phenylmagnesium bromide)
- m. (CH3)2CHMgBr
- n. CrO3
### Instructions:
Indicate the letters of the reagents you would use in the appropriate boxes for each step:
**Reagent for step 1:** [ ]
**Reagent for step 2:** [ ]
### Explanation:
1. **Step 1: Formation of Acid Chloride**
- To convert a formyl group (—CHO) to an acid chloride (—COCl), the appropriate reagent is thionyl chloride (SOCl2).
2. **Step 2: Grignard Reaction**
- To convert an acid chloride into a trans-styrene derivative, a Grignard reagent such as phenylmagnesium bromide (C6H5MgBr) can be used.
### Correct Reagents:
- **Reagent for step 1:** e. SOCl2
- **Reagent for step 2:** l. C6H5MgBr (phenylmagnesium bromide)
Complete the boxes as follows:
**Reagent for step 1:** e
**Reagent for step 2:** l](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fe5309a50-92ea-42e3-946e-c637f882638a%2F50258870-4152-4f33-b905-fe504d543f7e%2Fn2kz1v_processed.png&w=3840&q=75)
Transcribed Image Text:## Synthesis Problem Exercise
### Objective:
Specify the reagent you would use in each step of the following synthesis:
### Reaction Scheme:
The diagram depicts a two-step synthesis starting with a benzaldehyde (structure with a benzene ring attached to a formyl group (—CHO)).
1. **Step 1**: The formyl group (—CHO) on the benzene ring is transformed to an acid chloride group (—COCl).
2. **Step 2**: The acid chloride group (—COCl) is further reacted to form a compound with a benzene ring attached to a trans-styrene group (—CH=CH—C6H5).
### Reagents Available:
A list of letters (a to n) corresponding to different chemical reagents are provided:
- a. LiAlH4
- b. H2SO4
- c. HCl
- d. HBr
- e. SOCl2
- f. PBr3
- g. Dess-Martin periodinane (DMP)
- h. NaH
- i. NaOH
- j. CH3MgBr
- k. CH3CH2MgBr
- l. C6H5MgBr (phenylmagnesium bromide)
- m. (CH3)2CHMgBr
- n. CrO3
### Instructions:
Indicate the letters of the reagents you would use in the appropriate boxes for each step:
**Reagent for step 1:** [ ]
**Reagent for step 2:** [ ]
### Explanation:
1. **Step 1: Formation of Acid Chloride**
- To convert a formyl group (—CHO) to an acid chloride (—COCl), the appropriate reagent is thionyl chloride (SOCl2).
2. **Step 2: Grignard Reaction**
- To convert an acid chloride into a trans-styrene derivative, a Grignard reagent such as phenylmagnesium bromide (C6H5MgBr) can be used.
### Correct Reagents:
- **Reagent for step 1:** e. SOCl2
- **Reagent for step 2:** l. C6H5MgBr (phenylmagnesium bromide)
Complete the boxes as follows:
**Reagent for step 1:** e
**Reagent for step 2:** l
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