Sickle cell anemia is caused by—     a mutation in a cell surface receptor.     malfunction of an ion channel.     a mutation in the beta subunit of hemoglobin.     deficiency of foliate and iron.     none of the above.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Sickle cell anemia is caused by—

   

a mutation in a cell surface receptor.

   

malfunction of an ion channel.

   

a mutation in the beta subunit of hemoglobin.

   

deficiency of foliate and iron.

   

none of the above.

Expert Solution
Step 1 Introduction

Sickle cell Disease or SCD is one of the blood diseases that are usually inherited. The most commonly occuring SCD is Sickle Cell anemia. The main feature of this disease is an abnormality found in the oxygen carrying molecule hemoglobin of the red blood cells. This leads to sickle-shape of the cells in most cases.

A term known as "sickle cell crisis" explains all the acute state conditions that occurs in a patient with SCD, which includes:

hemolytic crisis: drops in the levels of hemoglobin,

vaso-occlussive crisis: obstructs the cappilaries and blood flow to organs,

spleen-sequestration crisis: affects the spleen,

aplastic crisis: worsening of anemia

 

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