Shingles A research doctor has discovered a new oint-ment that she believes will be more effective than the current medication in the treatment of shingles (a painfulskin rash). Eight patients have volunteered to participate in the initial trials of this ointment. You are the statisti-cian hired as a consultant to help design a completely randomized experiment.a) Describe how you will conduct this experiment.b) Suppose the eight patients’ last names start with theletters A to H. Using the random numbers listed below,show which patients you will assign to each treatment.Explain your randomization procedure clearly.41098 18329 78458 31685 55259c) Can you make this experiment double-blind? How?d) The initial experiment revealed that males and females may respond differently to the ointment. Further test-ing of the drug’s effectiveness is now planned, and many patients have volunteered. What changes in yourfirst design, if any, would you make for this secondstage of testing?

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Author:Amos Gilat
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Shingles A research doctor has discovered a new oint-
ment that she believes will be more effective than the
current medication in the treatment of shingles (a painful
skin rash). Eight patients have volunteered to participate
in the initial trials of this ointment. You are the statisti-
cian hired as a consultant to help design a completely
randomized experiment.
a) Describe how you will conduct this experiment.
b) Suppose the eight patients’ last names start with the
letters A to H. Using the random numbers listed below,
show which patients you will assign to each treatment.
Explain your randomization procedure clearly.
41098 18329 78458 31685 55259
c) Can you make this experiment double-blind? How?
d) The initial experiment revealed that males and females
may respond differently to the ointment. Further test-
ing of the drug’s effectiveness is now planned, and
many patients have volunteered. What changes in your
first design, if any, would you make for this second
stage of testing?
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