Sensipar Polarity and Solubility Predictions 1. Draw your molecule (or print out the line structure) on a separate paper. 2. For each central atom in your molecule, decide if it is polar or nonpolar. 3. For those central atoms that are polar a. color the central atom RED if it forms hydrogen bonds. b. color the central atom GREEN if it forms dipole-dipole interactions 4. Make a reasonable prediction stating whether your molecule will be soluble and explain your reasoning. If your molecule seems to be borderline in polarity, making it difficult to predict solubility, explain your reasoning and the difficulty involved. 5. Find a source (Pubchem, Merck Index, PDR, RxList etc.) that discusses the water-solubility of your drug. Compare your predictions with the information you find on the water-solubility of your drug and comment on any discrepancies.
Sensipar
Polarity and Solubility Predictions
1. Draw your molecule (or print out the line structure) on a separate paper.
2. For each central atom in your molecule, decide if it is polar or nonpolar.
3. For those central atoms that are polar
a. color the central atom RED if it forms hydrogen bonds.
b. color the central atom GREEN if it forms dipole-dipole interactions
4. Make a reasonable prediction stating whether your molecule will be soluble and explain your reasoning. If your molecule seems to be borderline in polarity, making it difficult to predict solubility, explain your reasoning and the difficulty involved.
5. Find a source (Pubchem, Merck Index, PDR, RxList etc.) that discusses the water-solubility of your drug. Compare your predictions with the information you find on the water-solubility of your drug and comment on any discrepancies.
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