Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (N in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI dipole-dipole hydrogen bond polarizability, size; molecular weight ionic interaction Species able to form that NCI any species with permanent dipoles (C-O, etc.) H bonded to N, O, or F and F a dielectric size; type of charge Parameters affecting the NCI ions; charged species strength and orientation of dipole orientation dispersion

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCI)
in the binding site. Assume the drug has a variety of types of polar and nonpolar regions.
Type of NCI
dipole-dipole
hydrogen bond
polarizability, size;
molecular weight
ionic interaction
Incorrect
Species able to form that NCI
any
species with permanent
dipoles (C-O, etc.)
H bonded to N, O, or F and
F
dielectric size; type
of charge
Answer Bank
Parameters affecting the NCI
ions; charged species
strength and orientation
of dipole
orientation
dispersion
Resources C
O
Transcribed Image Text:Macmillan Learning Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCI) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI dipole-dipole hydrogen bond polarizability, size; molecular weight ionic interaction Incorrect Species able to form that NCI any species with permanent dipoles (C-O, etc.) H bonded to N, O, or F and F dielectric size; type of charge Answer Bank Parameters affecting the NCI ions; charged species strength and orientation of dipole orientation dispersion Resources C O
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