Rh D - negative individuals generate an immune response when are exposed to the Rh -D antigen . However, incompatibility in the ABO blood group system occurs naturally in the absence pf expsure to the A or B antigen in the blood from another individual. Why do individuals produce an immune response the first time encounter the A or B antigen as an adult?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter17: Genes And The Immune System
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 Rh D - negative individuals generate an immune response when are exposed to the Rh -D antigen . However, incompatibility in the ABO blood group system occurs naturally in the absence pf expsure to the A or B antigen in the blood from another individual. Why do individuals produce an immune response the first time encounter the A or B antigen as an adult?  

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