Review Figures 8.12 and 8.13. In cells, the primers forDNA synthesis are short strands of RNA, so each newlysynthesized strand of DNA has a segment of RNA atits 5′ end. As replication proceeds, DNA polymerasesremove these RNA segments and fill in the resulting gapswith DNA. However, the gaps at the very 5′ ends of thenew strands cannot be filled in with DNA. Why not?DNA replication leaves exposed about 100 nucleotidesat the 5′ end of each template strand, and these singlestranded ends are removed. What are the effects of this“end problem” on a cell’s DNA as it continues to divide

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Review Figures 8.12 and 8.13. In cells, the primers for
DNA synthesis are short strands of RNA, so each newlysynthesized strand of DNA has a segment of RNA at
its 5′ end. As replication proceeds, DNA polymerases
remove these RNA segments and fill in the resulting gaps
with DNA. However, the gaps at the very 5′ ends of the
new strands cannot be filled in with DNA. Why not?
DNA replication leaves exposed about 100 nucleotides
at the 5′ end of each template strand, and these singlestranded ends are removed. What are the effects of this
“end problem” on a cell’s DNA as it continues to divide

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