Can you answer this question and show all your work clearly please.Question: Calculate the theoretical yield for this reaction.Part 1.Add 05 g of acetaminophen to a 25 mL round bottom flaskclamp this flask to a ring stand so that it can remain suspended in the air before you do anything elseAdd a stir bar to the flaskAdd 8 mL of the 1M ethanolic NaOH to the flask.Begin stirring the solutionEquip the flask with a reflux condenser with water flowingPut the reflux condenser onto the ring stand with a second clampWater flows in through the bottom and out through the topReflux the solution for 15 minStart the hot plate at 120 CAfter 15 min, raise the flask and condenser a few inches above the hot plate so that it can coolPart 2.Add 0.75 mL of bromoethane to the reaction by pouring it through the condenserReflux the solution for an additional 15 minAfter the solution has finished refluxing, allow it to cool enough to handle.Obtain a TLC plate and set up 3 lanesspot a sample of the acetaminophen provided in lane 1spot a sample of this reaction mixture in lane 2Pour the solution into a beaker containing 10 mL of ice and 10 mL of water.if the solution is still warm, cool it on an ice bathCollect the solid that forms by vacuum filtrationPart 3.Recrystallize the crude solid from ethanol and waterCollect the final solid by vacuum filtrationallow the solid to dry over airtake a small amount of solid, dissolve it in ethanol and spot it in lane 3 of your TLC plate Reaction:A Williamson ether synthesis' involves an alcohol and an alkyl halide reacting to form an ether.The first step is the deprotonation of the alcohol using a sufficiently strong base. In thisexperiment, the base used will be sodium hydroxide which has been dissolved in ethanol. Theresulting alkoxide, a phenoxide in this case, attacks the alkyl halide in an SN2 fashion. The finalproduct, phenacetin, is soluble in ethanol but insoluble in water, which will allow it to be purifiedbefore analysis.OH1. 1M NaOH in EtOHH2. СH3CH2-BrHNa* Br

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Answered: Reaction: A Williamson ether synthesis'…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Can you answer this question and show all your work clearly please.

Question: Calculate the theoretical yield for this reaction.

Part 1.

Add 05 g of acetaminophen to a 25 mL round bottom flask
1. clamp this flask to a ring stand so that it can remain suspended in the air before you do anything else
Add a stir bar to the flask
Add 8 mL of the 1M ethanolic NaOH to the flask.
1. Begin stirring the solution
Equip the flask with a reflux condenser with water flowing
1. Put the reflux condenser onto the ring stand with a second clamp
2. Water flows in through the bottom and out through the top
Reflux the solution for 15 min
1. Start the hot plate at 120 C
After 15 min, raise the flask and condenser a few inches above the hot plate so that it can cool

Part 2.

Add 0.75 mL of bromoethane to the reaction by pouring it through the condenser
Reflux the solution for an additional 15 min
After the solution has finished refluxing, allow it to cool enough to handle.
Obtain a TLC plate and set up 3 lanes
1. spot a sample of the acetaminophen provided in lane 1
2. spot a sample of this reaction mixture in lane 2
Pour the solution into a beaker containing 10 mL of ice and 10 mL of water.
1. if the solution is still warm, cool it on an ice bath
Collect the solid that forms by vacuum filtration

Part 3.

Recrystallize the crude solid from ethanol and water
Collect the final solid by vacuum filtration
1. allow the solid to dry over air
2. take a small amount of solid, dissolve it in ethanol and spot it in lane 3 of your TLC plate

Reaction:
A Williamson ether synthesis' involves an alcohol and an alkyl halide reacting to form an ether.
The first step is the deprotonation of the alcohol using a sufficiently strong base. In this
experiment, the base used will be sodium hydroxide which has been dissolved in ethanol. The
resulting alkoxide, a phenoxide in this case, attacks the alkyl halide in an SN2 fashion. The final
product, phenacetin, is soluble in ethanol but insoluble in water, which will allow it to be purified
before analysis.
OH
1. 1M NaOH in EtOH
H
2. СH3CH2-Br
H
Na* Br

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