Rate of glucose transport 0 The below graph plots the rate of glucose transport through a membrane transporter vs glucose concentration in blood. These glucose transporters are most prevalent in which of the listed types of tissues? MARK ALL THAT APPLY 100 200 300 400 500 Concentration of glucose in mg/dl 600
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- Explain what excretion rates of the glucose are when the plasma concentration of glucose is 1. 100mg/100 mL 2.350mg/100 mL (this only needs to be an estimation/prediction of glucose excretion ,not actual numbers)One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?Describe the hallmarks of the GLUT transporter – a passive glucose transporter, and the basis behind glucose transport in erythrocytes. Note: please answer above questions using the principles pertaining to biochemistry.
- (b) The GLUT system is highly selective for glucose. It also speeds up the rate of glucose transport across the membrane by as much as 100-fold when compared to the passive diffusion of glucose across a bilayer in the absence of any transport system. While impressive, this rate of transport is much slower than purely diffusion limited rate of movement (ie. the fastest a molecule can move by diffusion). Given this fact, on the blank plot below draw the expected relationship between the rate of GLUT-mediated transport and increasing [glucose]? Use the space below the graph to explain your answer. fast Transport Rate slow low [glucose] high (c) Next, use a dashed line on the same plot above to draw the shape of the curve when the amount of GLUT transporters in the membrane is cut in half. Briefly explain your answer in the space provided below the graph.What is the relationship between plasma glucose concentration and excretion rate of glucose? How does the concept of transport maximum relate to this?Glucose cannot enter easily inside the cell and require insulin to do so.What type of transport/movement does glucose exhibit?
- A 500 mL infusion of glucose 5% is being given at a rate of 167 mL/hr. How long will the infusion run at the specified rate?Define extracellular material (ECM). Explain how matrix metalloproteinases and tissue inhibitor of metalloproteinases regulates ECMWhen blood glucose level rises, the pancreas secretes insulin, and as a result blood glucose level declines. When blood glucose level is low, the pancreas secretes glucagon, and as a result blood glucose level rises. Such regulation of blood glucose level is the result of A reproduction thermal regulation community homeostasis 2,279 12 tv N MacBook Air DII DD F1 F2 F3 F4 F5 F6 F7 F8 F9 F10 F1 @ %23 24 2 6. %3D * CO
- Cotransport systems of the internal epithelial cells include the _____ in the intestine facing membrane, the energy requiring _____ facing the blood, and the ________ allowing facilitated diffusuon of glucose out of the cell.If a skeletal muscle has depleted its stores of ATP how will the altered transport properties of the following transporters affect cytosolic ion concentrations (increase, decrease, no change) relative to normal? Skeletal Muscle Cell With Depleted ATP Stores Ion transporter Cytosolic K+ Cytosolic Na+ Cytosolic Ca2+ NKA NCX SERCADefine sodium–glucose transporter (SGLT)
