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QUESTION 8 In the Results section of the paper, the authors' write: "Previous publications have shown that EGFR mutations are rare in human soft tissue sarcomas; therefore, activation of EGFR in studied specimens was possibly the result of appropriate ligand binding. To confirm this hypothesis, we analyzed the expression of EGF and TGF-alpha, the ligands for the EGFR. In the tumor microenvironment, EGFR ligands can be secreted both by tumor cells as well as by tumor-associated macrophages and fibroblasts." In the statement above, what text best refers to paracrine signaling? O "EGFR mutations" O "EGFR ligands can be secreted both by tumor cells" O "as well as by tumor-associated macrophages and fibroblasts" O "appropriate ligand binding"

QUESTION 8 In the Results section of the paper, the authors' write: "Previous publications have shown that EGFR mutations are rare in human soft tissue sarcomas; therefore, activation of EGFR in studied specimens was possibly the result of appropriate ligand binding. To confirm this hypothesis, we analyzed the expression of EGF and TGF-alpha, the ligands for the EGFR. In the tumor microenvironment, EGFR ligands can be secreted both by tumor cells as well as by tumor-associated macrophages and fibroblasts." In the statement above, what text best refers to paracrine signaling? O "EGFR mutations" O "EGFR ligands can be secreted both by tumor cells" O "as well as by tumor-associated macrophages and fibroblasts" O "appropriate ligand binding"

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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QUESTION 8 In the Results section of the paper, the authors' write: "Previous publications have shown that EGFR mutations are rare in human soft tissue sarcomas; therefore, activation of EGFR in studied specimens was possibly the result of appropriate ligand binding. To confirm this hypothesis, we analyzed the expression of EGF and TGF-alpha, the ligands for the EGFR. In the tumor microenvironment, EGFR ligands can be secreted both by tumor cells as well as by tumor-associated macrophages and fibroblasts." In the statement above, what text best refers to paracrine signaling? "EGFR mutations" O "EGFR ligands can be secreted both by tumor cells" "as well as by tumor-associated macrophages and fibroblasts" "appropriate ligand binding" QUESTION 9 For the following questions, refer to the PDF handout “EGFR mutations". This handout is from the company ATCC; they sell cancer cells to researchers for experiments. This page is titled "EGFR GENETIC ALTERATION PANEL. The first paragraph mentions "EGFR/ERBB1/HER1." What does “EGFR/ERBB1/HER1" mean? These refer to EGFR and two of its ligands. These are 3 EGFR family members. These are 3 ligands for EGFR. These are 3 names for the same proteins. OOO0
Transcribed Image Text:QUESTION 8 In the Results section of the paper, the authors' write: "Previous publications have shown that EGFR mutations are rare in human soft tissue sarcomas; therefore, activation of EGFR in studied specimens was possibly the result of appropriate ligand binding. To confirm this hypothesis, we analyzed the expression of EGF and TGF-alpha, the ligands for the EGFR. In the tumor microenvironment, EGFR ligands can be secreted both by tumor cells as well as by tumor-associated macrophages and fibroblasts." In the statement above, what text best refers to paracrine signaling? "EGFR mutations" O "EGFR ligands can be secreted both by tumor cells" "as well as by tumor-associated macrophages and fibroblasts" "appropriate ligand binding" QUESTION 9 For the following questions, refer to the PDF handout “EGFR mutations". This handout is from the company ATCC; they sell cancer cells to researchers for experiments. This page is titled "EGFR GENETIC ALTERATION PANEL. The first paragraph mentions "EGFR/ERBB1/HER1." What does “EGFR/ERBB1/HER1" mean? These refer to EGFR and two of its ligands. These are 3 EGFR family members. These are 3 ligands for EGFR. These are 3 names for the same proteins. OOO0
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