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Question 4. The titration curve for histidine is shown below. The pK values for the carboxyl group (pK₁) and the amino groups (pK₂) are shown. The pK value of the side chain is indicated as PKR. (a) 10 8 PH 6 MG&D 2014/1 4 2 0 COO™ Histidine (Difficulty = 2; LO 1.8) H₂N-CH CH₂ pK₁ = 1.82 Indicate which of the 4 ionisation species shown predominate at pH 1, 3, 7 and 11. H PKR = 6.0 1.0 OH (equivalents) COOH H₂N-CH CH₂ 2.0 H pK₂ = 9.17 H H COO H₂N-CH CH₂ H 3.0 H Pane 10 COO™ H₂N-CH CH₂ H H (b) The protonated (charged) form of the side chain of histidine is believed to be important for the functioning of a particular enzyme. At pH 7, what percentage of the enzyme will be active? (Difficulty = 2/3; LO 1.5, 1.8)

Question 4. The titration curve for histidine is shown below. The pK values for the carboxyl group (pK₁) and the amino groups (pK₂) are shown. The pK value of the side chain is indicated as PKR. (a) 10 8 PH 6 MG&D 2014/1 4 2 0 COO™ Histidine (Difficulty = 2; LO 1.8) H₂N-CH CH₂ pK₁ = 1.82 Indicate which of the 4 ionisation species shown predominate at pH 1, 3, 7 and 11. H PKR = 6.0 1.0 OH (equivalents) COOH H₂N-CH CH₂ 2.0 H pK₂ = 9.17 H H COO H₂N-CH CH₂ H 3.0 H Pane 10 COO™ H₂N-CH CH₂ H H (b) The protonated (charged) form of the side chain of histidine is believed to be important for the functioning of a particular enzyme. At pH 7, what percentage of the enzyme will be active? (Difficulty = 2/3; LO 1.5, 1.8)

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Question 4. The titration curve for histidine is shown below. The pK values for the carboxyl group (pK₁) and the amino groups (pK2) are shown. The pK value of the side chain is indicated as PKR. (a) 10- Histidine 8 PH 6 MG&D 2014/15 4 2 (Difficulty = 2; LO 1.8) pk₁ = 1.82 ___== H₂N-CH PKR = 6.0 Indicate which of the 4 ionisation species shown predominate at pH 1, 3, 7 and 11. H 2.0 pK₂ = 9.17 1.0 OH (equivalents) COOH H₂N-CH H₂N-CH CH₂ CH₂ 1111 H H H COO™ 3.0 H H Pane 10 COO™ H₂N-CH CH₂ H H -N (b) The protonated (charged) form of the side chain of histidine is believed to be important for the functioning of a particular enzyme. At pH 7, what percentage of the enzyme will be active? (Difficulty = 2/3; LO 1.5, 1.8)
Transcribed Image Text:Question 4. The titration curve for histidine is shown below. The pK values for the carboxyl group (pK₁) and the amino groups (pK2) are shown. The pK value of the side chain is indicated as PKR. (a) 10- Histidine 8 PH 6 MG&D 2014/15 4 2 (Difficulty = 2; LO 1.8) pk₁ = 1.82 ___== H₂N-CH PKR = 6.0 Indicate which of the 4 ionisation species shown predominate at pH 1, 3, 7 and 11. H 2.0 pK₂ = 9.17 1.0 OH (equivalents) COOH H₂N-CH H₂N-CH CH₂ CH₂ 1111 H H H COO™ 3.0 H H Pane 10 COO™ H₂N-CH CH₂ H H -N (b) The protonated (charged) form of the side chain of histidine is believed to be important for the functioning of a particular enzyme. At pH 7, what percentage of the enzyme will be active? (Difficulty = 2/3; LO 1.5, 1.8)
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