Question 33 Orciprenaline (C₁H₁7NO3, 211.258 g/mol) is a bronchodilator used in the treatment of asthma. The BP assay for orciprenaline tablets is described below. "Weigh and powder 20 tablets. Shake a quantity of the powder containing 80 mg of orciprenaline sulphate with 50 mL of 0.01 M hydrochloric acid (HCI), filter and add sufficient 0.01 M HCI to the filtrate to produce 100 mL. The following information was obtained during the assay: Weight of 20 tablets = 2.5564 g HO Weight of tablet powder assayed = 0.5266 g Absorbance reading = 0.5868 Stated content per tablet = 20 mg A (1%, 1 cm) at 276 nm = 72.3 OH Orciprenaline Dilute 10 mL to 100 mL with 0.01 M HCl and measure the absorbance of the resulting solution at the maximum at 276 nm." OH H N

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Question 33
Orciprenaline (C₁₁H₁7NO3, 211.258 g/mol) is a bronchodilator used in the treatment of
asthma. The BP assay for orciprenaline tablets is described
below.
HO
The following information was obtained during the assay:
Weight of 20 tablets = 2.5564 g
Weight of tablet powder assayed = 0.5266 g
Absorbance reading - 0.5868
Stated content per tablet = 20 mg
A (1%, 1 cm) at 276 nm = 72.3
OH H
N
OH
"Weigh and powder 20 tablets. Shake a quantity of the
powder containing 80 mg of orciprenaline sulphate with 50
mL of 0.01 M hydrochloric acid (HCI), filter and add
sufficient 0.01 M HCI to the filtrate to produce 100 mL.
Dilute 10 mL to 100 mL with 0.01 M HCI and measure the absorbance of the resulting
solution at the maximum at 276 nm."
Orciprenaline
4
Answer the following questions, explaining your reasoning clearly.
a) Calculate the amount of orciprenaline in the tablet powder analyzed.
b) Calculate the average amount of orciprenaline per tablet.
c) Calculate the percentage of the stated content of the orciprenaline sulphate in the tablets.
Transcribed Image Text:Question 33 Orciprenaline (C₁₁H₁7NO3, 211.258 g/mol) is a bronchodilator used in the treatment of asthma. The BP assay for orciprenaline tablets is described below. HO The following information was obtained during the assay: Weight of 20 tablets = 2.5564 g Weight of tablet powder assayed = 0.5266 g Absorbance reading - 0.5868 Stated content per tablet = 20 mg A (1%, 1 cm) at 276 nm = 72.3 OH H N OH "Weigh and powder 20 tablets. Shake a quantity of the powder containing 80 mg of orciprenaline sulphate with 50 mL of 0.01 M hydrochloric acid (HCI), filter and add sufficient 0.01 M HCI to the filtrate to produce 100 mL. Dilute 10 mL to 100 mL with 0.01 M HCI and measure the absorbance of the resulting solution at the maximum at 276 nm." Orciprenaline 4 Answer the following questions, explaining your reasoning clearly. a) Calculate the amount of orciprenaline in the tablet powder analyzed. b) Calculate the average amount of orciprenaline per tablet. c) Calculate the percentage of the stated content of the orciprenaline sulphate in the tablets.
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