Question 2. The reduction of 5-dehydroshikimate to shikimate is achieved by a dehydrogenase enzyme from P. sativum in the presence of the cofactor NADPH: میگه OH 5-dehydroshikimate Dehydrogenase enzyme NADPH - NADP+ a) Draw the full structure of NADPH. HO" CO₂ OH OH shikimate b) Provide a detailed arrow-pushing mechanism for the reduction of 5- dehydroshikimate by NADPH (for simplicity, you can abbreviate ADP as R). c) Identify which face (Re or Si) of the keto group in 5-dehydroshikimate the hydride addition occurred. d) Assign the R/S configuration for the newly formed alcohol stereocenter in shikimate.
Question 2. The reduction of 5-dehydroshikimate to shikimate is achieved by a dehydrogenase enzyme from P. sativum in the presence of the cofactor NADPH: میگه OH 5-dehydroshikimate Dehydrogenase enzyme NADPH - NADP+ a) Draw the full structure of NADPH. HO" CO₂ OH OH shikimate b) Provide a detailed arrow-pushing mechanism for the reduction of 5- dehydroshikimate by NADPH (for simplicity, you can abbreviate ADP as R). c) Identify which face (Re or Si) of the keto group in 5-dehydroshikimate the hydride addition occurred. d) Assign the R/S configuration for the newly formed alcohol stereocenter in shikimate.
Chapter29: The Organic Chemistry Of Metabolic Pathways
Section29.SE: Something Extra
Problem 23MP: One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of...
Related questions
Question
AI-Generated Solution
AI-generated content may present inaccurate or offensive content that does not represent bartleby’s views.
Unlock instant AI solutions
Tap the button
to generate a solution
Recommended textbooks for you
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,