Protein hydrolysis is an exergonic process,yet the 26S proteasome is dependent on ATP hydrolysis for activity. (a) Explain why ATP hydrolysis is required by the 26S proteasome. (b) Small peptides can be hydrolyzed without the expenditure of ATP. How does this information concur with your answer to part a ?
Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
Protein hydrolysis is an exergonic process,yet the 26S proteasome is dependent on ATP hydrolysis for
activity.
(a) Explain why ATP hydrolysis is required by the 26S proteasome.
(b) Small peptides can be hydrolyzed without the expenditure of ATP. How does this information concur with your answer to part a ?
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