Propose an efficient synthesis for each of the following steps. O-

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**Synthesis Pathway Example**

**Objective:**
Propose an efficient synthesis for each of the following steps.

The diagram represents a stepwise chemical transformation of a six-membered cyclic compound. Below are the observations and details of each transformation stage:

1. **Step 1:** 
   - The first structure is a cyclohexane ring with a bromine (Br) atom attached to one of the carbon atoms (a bromo-substituted cyclohexane).

2. **Step 2:** 
   - The second structure shows the same cyclohexane ring, but the bromine atom is replaced with a double bond (an alkene: cyclohexene).

3. **Step 3:** 
   - The third structure illustrates the cyclohexane ring with an OH group bonded to the carbon atom where the double bond was initially placed in the second structure (an alcohol: cyclohexanol).

4. **Step 4:**
   - The fourth structure shows the cyclohexane ring with a single oxygen atom connected by two bonds to the carbon atom, indicating the formation of an epoxide (an epoxycyclohexane).

5. **Step 5:**
   - The fifth structure displays the cyclohexane ring with an ester functional group attached to the carbon atom that originally had the OH group in the third structure, indicating the formation of a specific ester (ethyl cyclohexanecarboxylate).

This sequence of transformations demonstrates the conversion of a starting bromo-substituted cyclohexane into an esterified cyclohexane derivative. Each step indicates typical organic synthesis reactions involving substitution, addition, oxidation, and esterification processes.
Transcribed Image Text:**Synthesis Pathway Example** **Objective:** Propose an efficient synthesis for each of the following steps. The diagram represents a stepwise chemical transformation of a six-membered cyclic compound. Below are the observations and details of each transformation stage: 1. **Step 1:** - The first structure is a cyclohexane ring with a bromine (Br) atom attached to one of the carbon atoms (a bromo-substituted cyclohexane). 2. **Step 2:** - The second structure shows the same cyclohexane ring, but the bromine atom is replaced with a double bond (an alkene: cyclohexene). 3. **Step 3:** - The third structure illustrates the cyclohexane ring with an OH group bonded to the carbon atom where the double bond was initially placed in the second structure (an alcohol: cyclohexanol). 4. **Step 4:** - The fourth structure shows the cyclohexane ring with a single oxygen atom connected by two bonds to the carbon atom, indicating the formation of an epoxide (an epoxycyclohexane). 5. **Step 5:** - The fifth structure displays the cyclohexane ring with an ester functional group attached to the carbon atom that originally had the OH group in the third structure, indicating the formation of a specific ester (ethyl cyclohexanecarboxylate). This sequence of transformations demonstrates the conversion of a starting bromo-substituted cyclohexane into an esterified cyclohexane derivative. Each step indicates typical organic synthesis reactions involving substitution, addition, oxidation, and esterification processes.
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