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Programmed for IgM expression No loss of DNA Loss of DNA Variable region IgM IgD IgG IgE IgA Segment of DNA deleted B-cell DNA Programmed for IgM expression Programmed for IgG expression Variable region IgM IgD IgG IgE IgA Variable region IgG IgE IgA B-cell DNA B-cell DNA Plasma cells that develop from this B cell will produce IgM because that constant region gene segment is first in line. Plasma cells that develop from this B cell will produce IgG because the DNA loss now puts that constant region gene segment first in line. FIGURE 15.15 Class Switching Naive B cells are programmed to produce IgM antibodies. Activated B cells undergo class switching. Class switching does not alter the variable region and therefore has no effect on the antibody specificity. The plasma cells descended from B cells in lymph nodes most commonly produce IgG after class switching.

Programmed for IgM expression No loss of DNA Loss of DNA Variable region IgM IgD IgG IgE IgA Segment of DNA deleted B-cell DNA Programmed for IgM expression Programmed for IgG expression Variable region IgM IgD IgG IgE IgA Variable region IgG IgE IgA B-cell DNA B-cell DNA Plasma cells that develop from this B cell will produce IgM because that constant region gene segment is first in line. Plasma cells that develop from this B cell will produce IgG because the DNA loss now puts that constant region gene segment first in line. FIGURE 15.15 Class Switching Naive B cells are programmed to produce IgM antibodies. Activated B cells undergo class switching. Class switching does not alter the variable region and therefore has no effect on the antibody specificity. The plasma cells descended from B cells in lymph nodes most commonly produce IgG after class switching.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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How would this illustration change if it showed class switching by B cells residing in Peyer’s patches?

Programmed for IgM expression No loss of DNA Loss of DNA Variable region IgM IgD IgG IgE IgA Segment of DNA deleted B-cell DNA Programmed for IgM expression Programmed for IgG expression Variable region IgM IgD IgG IgE IgA Variable region IgG IgE IgA B-cell DNA B-cell DNA Plasma cells that develop from this B cell will produce IgM because that constant region gene segment is first in line. Plasma cells that develop from this B cell will produce IgG because the DNA loss now puts that constant region gene segment first in line. FIGURE 15.15 Class Switching Naive B cells are programmed to produce IgM antibodies. Activated B cells undergo class switching. Class switching does not alter the variable region and therefore has no effect on the antibody specificity. The plasma cells descended from B cells in lymph nodes most commonly produce IgG after class switching.
Transcribed Image Text:Programmed for IgM expression No loss of DNA Loss of DNA Variable region IgM IgD IgG IgE IgA Segment of DNA deleted B-cell DNA Programmed for IgM expression Programmed for IgG expression Variable region IgM IgD IgG IgE IgA Variable region IgG IgE IgA B-cell DNA B-cell DNA Plasma cells that develop from this B cell will produce IgM because that constant region gene segment is first in line. Plasma cells that develop from this B cell will produce IgG because the DNA loss now puts that constant region gene segment first in line. FIGURE 15.15 Class Switching Naive B cells are programmed to produce IgM antibodies. Activated B cells undergo class switching. Class switching does not alter the variable region and therefore has no effect on the antibody specificity. The plasma cells descended from B cells in lymph nodes most commonly produce IgG after class switching.
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