Procaine (its hydrochloride is marketed as Novocain) was one of the first local anesthet- ics for infiltration and regional anesthesia. See "Chemical Connections: From Cocaine to Procaine and Beyond."According to the following retrosynthetic scheme, procaine can be synthesized from 4-aminobenzoic acid, ethylene oxide, and diethylamine as sources of carbon atoms. HO. + HO NEt, H,N H,N' Procaine 4-Aminobenzoic acid Et,NH Ethylene oxide Diethylamine Provide reagents and experimental conditions to carry out the synthesis of procaine from these three compounds.

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Procaine (its hydrochloride is marketed as Novocain) was one of the first local anesthet-
ics for infiltration and regional anesthesia. See "Chemical Connections: From Cocaine
to Procaine and Beyond."According to the following retrosynthetic scheme, procaine
can be synthesized from 4-aminobenzoic acid, ethylene oxide, and diethylamine as
sources of carbon atoms.
HO.
+ HO
NEt,
H,N
H,N'
Procaine
4-Aminobenzoic acid
Et,NH
Ethylene oxide Diethylamine
Provide reagents and experimental conditions to carry out the synthesis of procaine
from these three compounds.
Transcribed Image Text:Procaine (its hydrochloride is marketed as Novocain) was one of the first local anesthet- ics for infiltration and regional anesthesia. See "Chemical Connections: From Cocaine to Procaine and Beyond."According to the following retrosynthetic scheme, procaine can be synthesized from 4-aminobenzoic acid, ethylene oxide, and diethylamine as sources of carbon atoms. HO. + HO NEt, H,N H,N' Procaine 4-Aminobenzoic acid Et,NH Ethylene oxide Diethylamine Provide reagents and experimental conditions to carry out the synthesis of procaine from these three compounds.
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