Predict the effects of the following compounds on intracellular nucleosidetriphosphate levels. For each answer, plot percent initial nucleotide levelas a function of time after administration of the agent, for each of the fournucleotides (semiquantitatively). Consider not only the primary effect ofthe compound but also any indirect effects on allosteric enzymes caused bynucleotide accumulation or depletion.(a) Effect of thymidine on dNTP levels(b) Effect of trimethoprim on bacterial rNTP levels(c) Effect of fluorodeoxyuridine on dNTP levels(d) Effect of hydroxyurea on dNTP levels

Predict the effects of the following compounds on intracellular nucleosidetriphosphate levels. For each answer, plot percent initial nucleotide levelas a function of time after administration of the agent, for each of the fournucleotides (semiquantitatively). Consider not only the primary effect ofthe compound but also any indirect effects on allosteric enzymes caused bynucleotide accumulation or depletion.(a) Effect of thymidine on dNTP levels(b) Effect of trimethoprim on bacterial rNTP levels(c) Effect of fluorodeoxyuridine on dNTP levels(d) Effect of hydroxyurea on dNTP levels

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter23: Enzymes

Section: Chapter Questions

Problem 23.32P: 2 The enzyme trypsin is synthesized by the body in the form of a long polypeptide chain containing...

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