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Please help explain how to find pKas of ionizable groups.

Please help explain how to find pKas of ionizable groups.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Please help explain how to find pKas of ionizable groups.
present in a pure sample of a protein. A mixture of three tripeptides - arg-val-his, lys-cys-phe, and cys-his-trp -was loaded onto the center of an isoelectric focusing gel, with the electrodes and a linear pH gradient as illustrated below, 26. arg-val-his, lys-cys-phe, cys-his-trp +, pH 3 pH 5 pH 7 pH 9 pH 11 (а) The pK,s of the amino and carboxy termini of these peptides are 9.4 and 2.2, respectively. What are the pKas of the ionizable side chains of the amino acids in these peptides? Write "N/A" in the blanks if there are no easily ionizable groups. val N/A phe a trp. arg his lys cys Ma On the diagram below, illustrate approximately where each of the three peptides will end up on the isoelectric focusing gel. (b) V K F w Arg pH 3 pH 5 pH 7 pH 9 pH 11
Transcribed Image Text:present in a pure sample of a protein. A mixture of three tripeptides - arg-val-his, lys-cys-phe, and cys-his-trp -was loaded onto the center of an isoelectric focusing gel, with the electrodes and a linear pH gradient as illustrated below, 26. arg-val-his, lys-cys-phe, cys-his-trp +, pH 3 pH 5 pH 7 pH 9 pH 11 (а) The pK,s of the amino and carboxy termini of these peptides are 9.4 and 2.2, respectively. What are the pKas of the ionizable side chains of the amino acids in these peptides? Write "N/A" in the blanks if there are no easily ionizable groups. val N/A phe a trp. arg his lys cys Ma On the diagram below, illustrate approximately where each of the three peptides will end up on the isoelectric focusing gel. (b) V K F w Arg pH 3 pH 5 pH 7 pH 9 pH 11
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