Imagine you are studying the genetic basis of gout using GWAS and have available molecular markers (single nucleotide polymorphism tags or SNP tags) located all over the genome. Your results are displayed below. -log, P-value 30 25 8 15 10- 5 ABCG2 I SLC2A9 ī Chromosome MYL2-CUX2 i O 11 12 13 14 15 16 17 18 19202122 a) From the plot above. Which chromosome/s would be the focus of your future studies in search of the genes that might be responsible for gout? Chromosome/s b) Briefly justify your choice/s for item a: I choose those chromosomes because c) You have made some assumptions to answer the previous item, please share them by filling in the blanks below: i) I am interpreting the results as: most of the patients that show gout symptoms also show allele/s for the SNP tag on chromosomes different alleles for the SNP tags on the other chromosomes. (the same/different) (please supply chormosome/s number/s as above), but an array of ii) My assumption about the relationship between gene distance (distance between the SNP tag and the candidate genes proposed as potential disease genes) and linkage disequilibrium (LD) is that the smaller the distance, the (higher/lower) the LD. iii) My assumption about the relationship between recombination rate and LD is that the higher the recombination rate, the (higher/lower) the LD.
Bacterial Genomics
The study of the morphological, physiological, and evolutionary aspects of the bacterial genome is referred to as bacterial genomics. This subdisciplinary field aids in understanding how genes are assembled into genomes. Further, bacterial or microbial genomics has helped researchers in understanding the pathogenicity of bacteria and other microbes.
Transformation Experiment in Bacteria
In the discovery of genetic material, the experiment conducted by Frederick Griffith on Streptococcus pneumonia proved to be a stepping stone.
Plasmids and Vectors
The DNA molecule that exists in a circular shape and is smaller in size which is capable of its replication is called Plasmids. In other words, it is called extra-chromosomal plasmid DNA. Vectors are the molecule which is capable of carrying genetic material which can be transferred into another cell and further carry out replication and expression. Plasmids can act as vectors.
please complete part C

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